当前位置: X-MOL 学术Theor. Biol. Med. Model. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Modelling the effect of a dengue vaccine on reducing the evolution of resistance against antibiotic due to misuse in dengue cases.
Theoretical Biology and Medical Modelling ( IF 2.432 ) Pub Date : 2020-05-13 , DOI: 10.1186/s12976-020-00125-8
Ana Kurauchi 1 , Claudio Jose Struchiner 2 , Annelies Wilder-Smith 3, 4 , Eduardo Massad 1, 2
Affiliation  

BACKGROUND This paper intends to check whether and how a hypothetical dengue vaccine could contribute to issue of evolution of bacteria resistance against antibiotics by reducing the number of patients that would inappropriately being treated with antibiotics. METHODS We use a new mathematical model that combines, in a novel way, two previously published papers, one on the evolution of resistance against antibiotics and one classical Ross-Macdonald model for dengue transmission. RESULTS The model is simulated numerically and reproduces a real case of evolution of resistance against antibiotics. In addition the model shows that the use of a hypothetical dengue vaccine could help to curb the evolution of resistance against an antibiotic inappropriately used in dengue patients. Both the increase in the proportion of resistant bacteria due to the misuse of antibiotics in dengue cases as a function of the fraction of treated patients and the reduction of that proportion as a function of vaccination coverage occur in a highly non-linear fashion. CONCLUSION The use of a dengue vaccine is helpful in reducing the rate of evolution of antibiotic resistance in a scenario of misuse of the antibiotics in dengue patients.

中文翻译:

模拟登革热疫苗在减少由于登革热病例中误用引起的对抗生素耐药性演变方面的作用。

背景技术本文旨在检查假想的登革热疫苗是否以及如何通过减少不适当地接受抗生素治疗的患者人数来促进细菌对抗生素耐药性的演变。方法我们使用一种新的数学模型,该模型以新颖的方式将之前发表的两篇论文结合在一起,一篇涉及对抗生素耐药性的演变,另一篇针对登革热传播的经典Ross-Macdonald模型。结果对该模型进行了数值模拟,并再现了对抗生素耐药性演变的真实案例。此外,该模型还表明,使用假想的登革热疫苗有助于遏制对登革热患者不适当使用的抗生素的耐药性。在登革热病例中由于滥用抗生素引起的耐药菌比例的增加(与所治疗患者的比例成函数关系)和与疫苗接种覆盖率的关系在该比例上的降低都以高度非线性的方式发生。结论在登革热患者滥用抗生素的情况下,使用登革热疫苗有助于降低抗生素耐药性的发生率。
更新日期:2020-05-13
down
wechat
bug