PURPOSE The aim of the present study was (i) to evaluate the safety and efficacy of aspiration thrombectomy in patients with M2 occlusions and (ii) to compare outcome of treatment of occlusion of different M2 segments. MATERIALS AND METHODS Between March 2016 and June 2019, 82 patients with acute ischemic stroke and isolated M2 occlusions were treated in cerebrovascular stroke center with aspiration thrombectomy as the first-line treatment. Functional outcomes of patients with different types of M2 occlusions were statistically compared. Multivariable logistic regression analysis was performed to determine the factors associated with good clinical outcome. RESULTS The mean age was 71.9 ± 13.4 years, 47.6% were men. Aspiration thrombectomy alone was utilized in 72.5% of patients, with 27.5% of patients being treated with a combination of aspiration thrombectomy and stent retriever. At the three-month follow-up, there was no statistically significant difference in functional outcome between different types of M2 occlusions (p = 0.662), however in the underpowered analysis because of the small sample size of patients, with good clinical outcome mRS 0-2 in 50% of all treated patients. Symptomatic intracranial hemorrhage was found in 6.1% of patients. Lower age (OR 0.932, 95% CI 0.878-0.988) and lower NIHSS score upon admission (OR 0.893, 95% CI 0.805-0.991) were independent predictors of good clinical outcome. CONCLUSION Aspiration thrombectomy appeared to be a safe and effective first-line treatment option for patients with M2 occlusion, being the first-line option for almost three-quarters of patients.

中文翻译：

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抽吸取栓作为 M2 闭塞的一线治疗。

目的 本研究的目的是 (i) 评估 M2 闭塞患者抽吸血栓切除术的安全性和有效性，以及 (ii) 比较不同 M2 节段闭塞的治疗结果。材料与方法 2016 年 3 月至 2019 年 6 月，82 例急性缺血性卒中合并孤立性 M2 闭塞患者在脑卒中中心接受治疗，以抽吸取栓为一线治疗。对不同类型 M2 闭塞患者的功能结果进行统计学比较。进行多变量逻辑回归分析以确定与良好临床结果相关的因素。结果 平均年龄为 71.9 ± 13.4 岁，47.6% 为男性。72.5% 的患者仅使用抽吸血栓切除术，其中 27%。5% 的患者接受血栓抽吸术和支架取出器的组合治疗。在三个月的随访中，不同类型的 M2 闭塞之间的功能结果没有统计学上的显着差异（p = 0.662），但由于患者样本量小，临床结果良好，因此在功效不足的分析中 mRS 0 -2 在所有接受治疗的患者中的 50%。在 6.1% 的患者中发现有症状的颅内出血。较低的年龄 (OR 0.932, 95% CI 0.878-0.988) 和入院时较低的 NIHSS 评分 (OR 0.893, 95% CI 0.805-0.991) 是良好临床结果的独立预测因素。结论 抽吸血栓切除术似乎是 M2 闭塞患者的安全有效的一线治疗选择，是近四分之三患者的一线选择。