ABSTRACT Background Findings from several studies have indicated that participants with nfvPPA and participants with svPPA exhibit different patterns on action and object naming tasks, while other recent studies have found that neither participants with nfvPPA nor participants with svPPA show a significant difference in accuracy between object naming and action naming. Aims The goal of this study was to test the hypothesis that relative action naming impairment is associated with grammatical ability in PPA, rather than a specific subtype of PPA. Methods & Procedures Thirty-four participants with PPA completed the Boston Naming Test, the Action Naming subtest of the Boston Diagnostic Aphasia Examination, and the Northwestern Anagram Test, which was used to measure grammatical ability. Z-scores for the two naming tasks were calculated based on normative data from unimpaired controls. For each participant with PPA, the relative action naming impairment was calculated by subtracting the object naming z-score from the action naming z-score. Linear regression analysis was then used to evaluate the role of grammatical ability as a predictor of relative action naming impairment, while controlling for age, education, cognitive ability (as measured by the Montreal Cognitive Assessment), and semantic ability (as measured by the Pyramids and Palm Trees test). The interaction between grammatical ability and each control variable was also examined. Outcomes & Results The main effect of grammatical ability was a significant predictor of relative action naming impairment, while none of the control variables was a significant predictor. However, the interaction between grammatical ability and semantic ability was also significant. Conclusions Individuals who have both grammatical impairment and semantic impairment have the largest relative action naming impairment. These individuals may benefit from a treatment that focuses on the retrieval of verbs and their arguments.

中文翻译：

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语法能力预测原发性进行性失语症的相对动作命名障碍

摘要背景 几项研究的结果表明，nfvPPA 参与者和 svPPA 参与者在动作和对象命名任务上表现出不同的模式，而最近的其他研究发现，nfvPPA 参与者和 svPPA 参与者在对象命名的准确性上都没有显着差异和动作命名。目的 本研究的目的是检验相对动作命名障碍与 PPA 的语法能力相关的假设，而不是与 PPA 的特定亚型相关的假设。方法与程序 34 名 PPA 参与者完成了波士顿命名测试、波士顿诊断性失语症检查的动作命名子测试和用于测量语法能力的西北字谜测试。两个命名任务的 Z 分数是根据来自未受损对照的规范数据计算的。对于每个 PPA 参与者，通过从动作命名 z 分数中减去对象命名 z 分数来计算相对动作命名障碍。然后使用线性回归分析评估语法能力作为相对动作命名障碍的预测因子的作用，同时控制年龄、教育、认知能力（通过蒙特利尔认知评估测量）和语义能力（通过金字塔测量和棕榈树测试）。还检查了语法能力和每个控制变量之间的相互作用。结果与结果 语法能力的主要影响是相对动作命名障碍的显着预测因子，而控制变量都不是显着的预测因子。然而，语法能力和语义能力之间的交互作用也很显着。结论同时具有语法障碍和语义障碍的个体具有最大的相对动作命名障碍。这些人可能会受益于专注于检索动词及其论点的治疗。