ABSTRACT The process of microbiota acquisition and microbiome development is complex and the perinatal period is key in both microbiome and immune development. In addition, the intestinal microbiome is increasingly being linked with later life morbidity and diseases such as Inflammatory Bowel Disease (IBD). It is pertinent to investigate whether perinatal events may influence intestinal microbiome development and therefore, have a role in the development of later life disease. This review will explore the current understanding of events that influence the developing intestinal microbiome in the perinatal period and how these events link to the development of IBD in later life. Establishing that perinatal events may protect or predispose to IBD in later life is of importance as there is potential to implement corrective measures. The perinatal period is a developmentally sensitive interval that offers opportunities to modify microbiome development. Understanding the processes of microbiome development, and understanding how we can tip the balance toward developing a robust and healthy microbiome, may have an essential role in minimising later-life disease and optimising later-life health.

中文翻译：

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围产期、发展中的肠道微生物群和炎症性肠病：早期生活事件与晚年疾病有什么联系？

摘要 微生物群获得和微生物组发育的过程是复杂的，围产期是微生物组和免疫发育的关键。此外，肠道微生物组越来越多地与晚年发病率和炎症性肠病 (IBD) 等疾病相关联。有必要研究围产期事件是否会影响肠道微生物群的发育，从而在晚年疾病的发展中发挥作用。本综述将探讨目前对影响围产期肠道微生物群发展的事件的理解，以及这些事件如何与以后生活中 IBD 的发展相关联。确定围产期事件可能在以后的生活中保护或易患 IBD 很重要，因为有可能实施纠正措施。围产期是一个发育敏感的时期，它提供了改变微生物组发育的机会。了解微生物组发育的过程，并了解我们如何在发展强大而健康的微生物组方面取得平衡，可能在最大限度地减少晚年疾病和优化晚年健康方面发挥重要作用。