ABSTRACT Convergent validation of a verbal incidental learning (IL) task from the WAIS-IV using neuroimaging biomarkers is warranted to understand its sensitivity to Alzheimer’s disease (AD) pathology. Fifty-five memory clinic patients aged 59 to 87 years received neuropsychological assessment, and measures of IL and quantitative brain imaging. Worse IL-Total Score and IL-Similarities performances were significantly associated with smaller hemispheric hippocampal volumes. IL measures were not significantly correlated with cerebral β-amyloid burden, though a trend was present and effect sizes were mild. These hippocampal volume results suggest that this IL task may be sensitive to AD pathology along the AD continuum.

中文翻译：

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检查来自 WAIS-IV 的言语偶然学习测量与阿尔茨海默病病理学神经影像生物标志物之间的关系

摘要 使用神经影像生物标志物对来自 WAIS-IV 的口头偶然学习 (IL) 任务进行收敛验证，以了解其对阿尔茨海默病 (AD) 病理学的敏感性。55 名 59 至 87 岁的记忆诊所患者接受了神经心理学评估、IL 和定量脑成像测量。更差的 IL 总分和 IL 相似性表现与较小的半球海马体积显着相关。IL 测量值与脑 β-淀粉样蛋白负荷没有显着相关性，尽管存在趋势且影响程度较轻。这些海马体积结果表明，该 IL 任务可能对沿 AD 连续体的 AD 病理敏感。