Abstract Joint-level rigid body dynamics simulations, when coupled with tissue-level finite element analyses, can simultaneously provide movement and tissue deformation metrics to understand mechanical interactions within the joint on a multi-scale level. In this study, a co-simulation workflow of a joint-level rigid body model that predicts the relative motion as a function of the non-linear cartilage response predicted by a non-linear implicit finite element solver is presented. Predictions are compared to in-vitro measurements (The Open Knee(s) project) in terms of the mean error and level-of-agreement: pressureerror = 0.46 MPa (level-of-agreement, −0.23 – 1.1 MPa); areaerror = −89 mm2 (level-of-agreement, −280 – 98 mm2) and contact forceerror = 93 N (level-of-agreement, 7.8 – 180 N). The automated co-simulation control algorithm enables multiscale coupling between joint and tissue-level models with real-time two-way communication as opposed to the traditional feed-forward approach of multi-scale models.

中文翻译：

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通过刚体动力学和非线性有限元分析的联合仿真预测髌股关节运动学和接触

摘要 关节级刚体动力学模拟与组织级有限元分析相结合，可以同时提供运动和组织变形指标，以在多尺度水平上了解关节内的机械相互作用。在这项研究中，提出了关节级刚体模型的联合仿真工作流程，该模型将相对运动预测为非线性隐式有限元求解器预测的非线性软骨响应的函数。在平均误差和一致性水平方面将预测与体外测量（开放膝关节项目）进行比较：压力误差 = 0.46 MPa（一致性水平，-0.23 – 1.1 MPa）；areaerror = -89 mm2（一致水平，-280 – 98 mm2）和接触力误差 = 93 N（一致水平，7.8 – 180 N）。