Abstract

Purpose/aim of the study

Subacute sclerosing panencephalitis (SSPE) is a degenerative disease of the brain caused by a persistent measles virus infection occurring mostly in childhood or early adolescence. The spectrum of epileptic phenomena associated with SSPE is wide, varying from partial or generalized tonic-clonic seizures and atypical absences to myoclonic-atonic attacks. Tonic seizures are very rare in SSPE.

Materials and methods

Herein, we discuss a case of 25 years old male that presented with adult-onset SSPE with tonic seizures accompanying myoclonic seizures.

Results

Patient was treated with clonazepam 5 mg/day and an isoprinosine regimen with a dose of 70 mg/kg/day. This is the fourth case of SSPE presenting with myoclonic and tonic seizures and the first case of SSPE with myoclonic and tonic seizures reported in an adult-onset case in the English literature.

Conclusions

Adult-onset SSPE with tonic seizures is rare and may be confusing, thus, it is important to recognize the presence of this type of tonic motor seizures in SSPE patients.

中文翻译：

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成人发作的亚急性硬化性全脑炎，表现为强直性运动性癫痫发作

摘要

研究目的/目的

亚急性硬化性全脑炎 (SSPE) 是一种由持续性麻疹病毒感染引起的大脑退行性疾病，主要发生在儿童期或青春期早期。与 SSPE 相关的癫痫现象范围很广，从部分或全身强直-阵挛发作和非典型失神到肌阵挛-失张力发作不等。强直性癫痫发作在 SSPE 中非常罕见。

材料和方法

在这里，我们讨论了一个 25 岁男性的病例，该病例出现成人发病的 SSPE，伴有肌阵挛性癫痫发作的强直性癫痫发作。

结果

患者接受氯硝西泮 5 mg/天和异丙嘧啶方案治疗，剂量为 70 mg/kg/天。这是第四例出现肌阵挛和强直性癫痫发作的 SSPE 病例，也是英国文献报道的成人发病病例中首例 SSPE 伴有肌阵挛和强直性癫痫发作的病例。

结论

伴有强直性癫痫发作的成人型 SSPE 很少见，可能会造成混淆，因此，重要的是要认识到 SSPE 患者存在这种类型的强直性运动性癫痫发作。