Abstract

Aim

The term habituation refers to the rapid loss of therapeutic effects that occurs following an initially beneficial adjustment of Deep Brain Stimulation (DBS) parameters. DBS habituation typically occurs over a period of days to weeks and has been observed in a subgroup of essential tremor (ET) patients undergoing stimulation of the ventral intermediate nucleus of the thalamus (VIM). The negative consequences of DBS habituation include protracted periods of ineffective therapy, the exacerbation of symptoms beyond presurgical levels (rebound), and the requirement for repeated office visits for stimulation adjustments.

Materials and methods

In this case series, we describe a programming strategy implemented in three patients with ET experiencing DBS habituation. This strategy involves the planned alternation between pre-programmed electrode configurations (‘groups’), performed by the patient prior to or in response to the loss of therapeutic efficacy in habituation.

Results/Conclusions: We provide here additional support for group alternation as a treatment option for DBS patients with ET complicated by tremor habituation.

中文翻译：

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重复组交替作为特发性震颤患者的编程策略，这些患者经历了深部脑刺激治疗的快速习惯

摘要

目标

习惯化一词是指在最初对脑深部刺激 (DBS) 参数进行有益调整后发生的治疗效果迅速丧失。DBS 习惯通常发生在数天到数周的时间内，并且已在接受刺激丘脑腹侧中间核 (VIM) 的特发性震颤 (ET) 患者亚组中观察到。DBS 习惯的负面后果包括长期无效治疗、症状恶化超过术前水平（反弹）以及需要重复就诊以调整刺激。

材料和方法

在这个案例系列中，我们描述了在三名患有 DBS 习惯的 ET 患者中实施的编程策略。该策略涉及预先编程的电极配置（“组”）之间的计划交替，由患者在习惯化治疗效果丧失之前或响应于丧失而执行。

结果/结论：我们在此为合并震颤习惯的 ET 患者提供组交替作为治疗选择的额外支持。