Abstract

Purpose

The aim of this study was to compare the blink rate (BR), tear tests, corneal parameters, and the thickness of each corneal sublayer in patients with Parkinson’s disease (PD) and healthy individuals.

Methods

A total of 64 eyes from 64 patients with PD and 64 eyes from 64 age- and sex-matched healthy individuals were included in this study. All participants underwent a detailed neurological and ophthalmological evaluation. The severity of disease was measured according to Hoehn–Yahr (H–Y) scale. The blink rate (BR), Schirmer test, and tear break-up time (TBUT) scores were assessed. Corneal parameters were measured using Pentacam. Additionally, the thickness of the corneal epithelium, Bowman layer, stroma, and Descemet membrane-endothelium complex were measured on the central cornea with anterior segment module of spectral domain optical coherence tomography (AS-OCT).

Results

The BR, Schirmer’s test, TBUT, pachymetric measurements, Bowman layer, and stromal thickness values of the patient group were significantly lower than those of the control group. The disease duration and disease severity were significantly negative correlated with the pachymetric measurements and stromal thickness. Also, the values of TBUT and the score of Schirmer test were significantly positive correlated with the pachymetric measurements and stromal thickness.

Conclusions

A reduced BR and poor tear quality in the PD, can result in reduced pachymetric measurements and stromal thickness.

中文翻译：

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帕金森病患者角膜亚层厚度和角膜参数的评估

摘要

目的

本研究的目的是比较帕金森病 (PD) 患者和健康个体的眨眼率 (BR)、撕裂测试、角膜参数和每个角膜亚层的厚度。

方法

本研究共包括 64 名 PD 患者的 64 只眼和 64 名年龄和性别匹配的健康人的 64 只眼。所有参与者都接受了详细的神经和眼科评估。根据Hoehn-Yahr（H-Y）量表测量疾病的严重程度。评估眨眼率 (BR)、Schirmer 测试和泪液破裂时间 (TBUT) 分数。使用 Pentacam 测量角膜参数。此外，还使用光谱域光学相干断层扫描 (AS-OCT) 的前段模块在中央角膜上测量了角膜上皮、鲍曼层、基质和 Descemet 膜-内皮复合体的厚度。

结果

患者组的BR、Schirmer's test、TBUT、厚度测量值、Bowman层和间质厚度值均显着低于对照组。疾病持续时间和疾病严重程度与厚度测量值和基质厚度呈显着负相关。此外，TBUT 的值和 Schirmer 测试的分数与厚度测量值和基质厚度呈显着正相关。

结论

PD 的 BR 降低和撕裂质量差，会导致厚度测量值和基质厚度降低。