Assessment of TREM2 rs75932628 variant’s association with Parkinson’s disease in a Greek population and Meta-analysis of current data,International Journal of Neuroscience

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Assessment of TREM2 rs75932628 variant’s association with Parkinson’s disease in a Greek population and Meta-analysis of current data
International Journal of Neuroscience ( IF 2.2 ) Pub Date : 2020-04-19 , DOI: 10.1080/00207454.2020.1750388
Efthimios Dardiotis ₁ , Dimitrios Rikos ₁ , Vasileios Siokas ₁ , Athina-Maria Aloizou ₁ , Zisis Tsouris ₁ , Evagelos Sakalakis ₁ , Alexandros G. Brotis ₂ , Dimitrios P. Bogdanos _{3,

4} , Georgios M. Hadjigeorgiou _{1,

5}

Affiliation

Abstract

Background

Α number of genetic variants are considered to confer susceptibility to Parkinson’s disease (PD). Rs75392628 (R47H), a rare variant of TREM2 gene, has been linked to PD, although its role on PD remains conflicting.

Objective

Detection of a possible contribution of rs75392628 variant of TREM2 gene to PD risk.

Methods

A total of 358 PD patients and 358 healthy controls genotyped for rs75392628. In addition, a meta-analysis was performed by merging our results with those from previous studies.

Results

The rare variant of rs75932628 (47H) of TREM2 gene was not detected on cohort. Meta-analysis of a total of 9271 PD cases and 9777 controls across 14 independent PD data sets from 9 studies, including the present study, did not show any statistically significant effect of rs75392628 on PD risk (OR_FE:1.54 95% CI:0.87-2.73. OR_RE: 1.54, 95%CI: 0.71-3.32).

Conclusions

Rs75392628 TREM2 variant is rather unlikely to be a major genetic risk contributor of PD.

中文翻译：

在希腊人群中评估TREM2 rs75932628变体与帕金森氏病的关联性和当前数据的荟萃分析

摘要

背景

许多遗传变异被认为赋予对帕金森氏病（PD）的敏感性。Rs75392628（R47H）是TREM2基因的罕见变体，尽管它在PD上的作用仍然存在冲突，但已与PD关联。

客观的

检测TREM2基因的rs75392628变体对PD风险的可能贡献。

方法

共有358名PD患者和358名健康对照者进行了rs75392628基因型分型。此外，通过将我们的结果与以前的研究结果进行合并，进行了荟萃分析。

结果

队列中未检测到TREM2基因的rs75932628（47H）的罕见变体。对包括本研究在内的9项研究的14个独立PD数据集进行的总共9271例PD病例和9777对照的荟萃分析未显示rs75392628对PD风险有任何统计学显着性影响（或_FE：1.54 95％CI：0.87 -2.73。或_RE：1.54，95％CI：0.71-3.32）。