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Renin angiotensin system blockage by losartan neutralize hypercholesterolemia-induced inflammatory and oxidative injuries.
Redox Report ( IF 3.8 ) Pub Date : 2020-05-12 , DOI: 10.1080/13510002.2020.1763714
Abdulaziz M S AlSaad 1 , Fawaz Alasmari 1 , Hatem M Abuohashish 2 , Mohamed Mohany 1 , Mohammed M Ahmed 1 , Salim S Al-Rejaie 1
Affiliation  

ABSTRACTObjectives: This study explores the protective role of losartan (LT) against oxidative and inflammatory damages in different physiological systems including heart, liver, and kidney tissue in hypercholesterolemic rats.Methods: After induction of hypercholesterolemia by high cholesterol diet for 6 weeks, LT was administered for 4 weeks. In serum, the levels of lipoproteins, aminotransferases, creatine kinases, urea, apoptosis, and inflammatory markers were measured. In cardiac, hepatic, and renal tissues, lipid peroxidation product and GSH as well as antioxidant enzymatic activities were assayed. Finally, histopathological assessment evaluated the structural damage in cardiac, hepatic, and renal tissues.Results: Serum markers of cardiac, hepatic, and renal toxicities including creatine kinases, aminotransferases, and urea were attenuated by LT in hypercholesterolemic animals. Moreover, LT markedly corrected the elevated levels of lipoproteins, apoptosis, and inflammatory biomarkers. Hypercholesterolemia-induced lipid peroxidation, low GSH levels, and diminished activities of antioxidant enzymes were prominently improved in LT treated animals. Histopathological alterations by hypercholesterolemia in heart, liver, and kidney tissues were ameliorated by LT.Conclusion: This study confirmed the pathological enrollment of renin-angiotensin system in hypercholesterolemia-associated metabolic alterations. LT had a significant cardiac, hepatic, and renal protective role against these impairments through down-regulation of oxidative damage, inflammation and necrosis.

中文翻译:

氯沙坦对肾素血管紧张素系统的阻断可中和高胆固醇血症引起的炎症和氧化损伤。

摘要:目的:本研究探讨氯沙坦(LT)对高胆固醇血症大鼠心脏,肝脏和肾脏等不同生理系统的氧化和炎症损害的保护作用。方法:高胆固醇饮食诱导高胆固醇血症6周后,LT给药4周。在血清中,检测脂蛋白,转氨酶,肌酸激酶,尿素,细胞凋亡和炎症标志物的水平。在心脏,肝脏和肾脏组织中,测定了脂质过氧化产物和GSH以及抗氧化剂的酶活性。最后,组织病理学评估评估了心脏,肝和肾组织的结构损伤。结果:心脏,肝和肾毒性的血清标志物包括肌酸激酶,氨基转移酶,高胆固醇血症动物的LT会降低尿素和尿素。此外,LT显着纠正了脂蛋白,细胞凋亡和炎症生物标志物水平的升高。高胆固醇血症引起的脂质过氧化,低谷胱甘肽水平和抗氧化酶活性降低在经LT治疗的动物中得到显着改善。LT改善了心,肝和肾组织中高胆固醇血症的组织病理学改变。结论:本研究证实了高胆固醇血症相关代谢改变中肾素-血管紧张素系统的病理学特征。LT通过下调氧化损伤,炎症和坏死而对这些损伤具有重要的心脏,肝脏和肾脏保护作用。LT显着纠正了脂蛋白,凋亡和炎症生物标志物水平的升高。高胆固醇血症引起的脂质过氧化,低谷胱甘肽水平和抗氧化酶活性降低在经LT治疗的动物中得到显着改善。LT改善了心,肝和肾组织中高胆固醇血症的组织病理学改变。结论:本研究证实了高胆固醇血症相关代谢改变中肾素-血管紧张素系统的病理学特征。LT通过下调氧化损伤,炎症和坏死而对这些损伤具有重要的心脏,肝脏和肾脏保护作用。LT显着纠正了脂蛋白,凋亡和炎症生物标志物水平的升高。高胆固醇血症引起的脂质过氧化,低谷胱甘肽水平和抗氧化酶活性降低在经LT治疗的动物中得到显着改善。LT改善了心,肝和肾组织中高胆固醇血症的组织病理学改变。结论:本研究证实了高胆固醇血症相关代谢改变中肾素-血管紧张素系统的病理学特征。LT通过下调氧化损伤,炎症和坏死而对这些损伤具有重要的心脏,肝脏和肾脏保护作用。LT处理动物的抗氧化酶活性显着提高。LT改善了心,肝和肾组织中高胆固醇血症的组织病理学改变。结论:本研究证实了高胆固醇血症相关代谢改变中肾素-血管紧张素系统的病理学特征。LT通过下调氧化损伤,炎症和坏死而对这些损伤具有重要的心脏,肝脏和肾脏保护作用。LT处理动物的抗氧化酶活性显着改善。LT改善了心,肝和肾组织中高胆固醇血症的组织病理学改变。结论:本研究证实了高胆固醇血症相关代谢改变中肾素-血管紧张素系统的病理学特征。LT通过下调氧化损伤,炎症和坏死而对这些损伤具有重要的心脏,肝脏和肾脏保护作用。
更新日期:2020-05-12
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