Objective: To compare the effects of intensity-matched acute exercise at different intensities on proinflammatory and anti-inflammatory cytokines between able-bodied (AB) and spinal cord injured (SCI) individuals.

Design: Non-Randomized Controlled Trial.

Setting: Community settings in São Paulo – Brazil.

Participants: Eight AB and nine SCI paraplegic.

Interventions: Participants underwent three exercise sessions at different relative intensities: at ventilatory threshold 1 intensity (VT1), 15% below VT1, and 15% above VT1. Similar energy expenditures were established from exercises with different intensities for each volunteer. The AB group was tested on a conventional treadmill, whereas the SCI group was tested on a treadmill adapted for wheelchair use. Blood samples were collected at baseline, immediately after, and 30 min after the exercise sessions.

Outcome measures: Interleukin 1 receptor antagonist, interleukin 1 beta, interleukin 2, interleukin 4, interleukin 6, interleukin 10 and tumoral necrosis factor alpha were measured.

Results: When groups were compared, interleukin – 2 was found higher, whereas interleukin – 4 and interleukin – 10 were found lower in the SCI group at all collection times in the three exercise intensities (all P < 0.05). Interleukin – 1 receptor antagonist was found higher immediately after exercise at VT1, 15% above VT1 and 30 min after 15% below VT1 in the AB group (all P < 0.05). In the AB group, an increase in interleukin – 6 immediately after the exercise at VT1 compared with baseline was found (P = 0.01).

Conclusion: Individuals with SCI may have to perform physical exercise at a higher volume or energy expenditure than AB individuals to obtain similar anti-inflammatory benefits of acute exercise.

Trial registration: Uniform Trial Number identifier: U1111-1232-8142.

目的：比较不同强度的强度匹配急性运动对健全（AB）和脊髓损伤（SCI）个体促炎和抗炎细胞因子的影响。

设计：非随机对照试验。

环境：巴西圣保罗的社区环境。

参与者：八名 AB 和九名 SCI 截瘫。

干预：参与者经历了三个不同相对强度的运动：通气阈值 1 强度 (VT1)、低于 VT1 的 15% 和高于 VT1 的 15%。从每个志愿者的不同强度的锻炼中建立了类似的能量消耗。AB 组在传统跑步机上进行测试，而 SCI 组在适合轮椅使用的跑步机上进行测试。在基线、运动后立即和运动后 30 分钟收集血样。

结果测量：测量了白细胞介素1受体拮抗剂、白细胞介素1β、白细胞介素2、白细胞介素4、白细胞介素6、白细胞介素10和肿瘤坏死因子α。

结果：当进行组比较时，在三种运动强度的所有采集时间，SCI 组的白细胞介素 - 2 较高，而白细胞介素 - 4 和白细胞介素 - 10 较低（均P  < 0.05）。发现白细胞介素-1 受体拮抗剂在 VT1 时立即升高，在 AB 组中高于 VT1 15% 和低于 VT1 15% 后 30 分钟（所有P  < 0.05）。在 AB 组中，与基线相比，在 VT1 运动后立即发现白细胞介素 - 6 增加（P  = 0.01）。

结论：与 AB 个体相比，SCI 个体可能必须以更高的体能或能量消耗进行体育锻炼，才能获得与急性锻炼相似的抗炎益处。

试用注册：统一试用编号标识符：U1111-1232-8142。