ABSTRACT The umbilical cord is the connecting link between the mother and the fetus and its morphology is an indicator of fetal well-being. Preeclampsia is a disorder of pregnancy associated with new-onset hypertension, which occurs most often after 20 weeks of gestation. There are structural differences in the umbilical cord of normotensive and hypertensive pregnant women. This research aimed to study the histology and histomorphometry of umbilical cord areas in preeclampsia and compare the parameters with normal uncomplicated pregnancies of gestational age 37–40 weeks. A total of 70 umbilical cords were studied from preeclampsia (n = 35) and normal (n = 35) pregnancies. The parameters studied included cross-sectional areas (CSA) of umbilical cord, umbilical vein lumen, umbilical vein wall, umbilical artery lumen, umbilical artery wall, and Wharton’s jelly, including the presence of edema in the vessel walls and Wharton’s jelly and basement membrane thickening. The mean umbilical cord CSA was significantly higher in preeclampsia (p = 0.014). The mean umbilical artery lumen CSA was significantly lower than the normal pregnancy cords (p = 0.006). The mean Wharton’s jelly CSA in preeclampsia was significantly higher than the normal pregnancy cords (p = 0.004). The parameters for umbilical vein lumen CSA, umbilical vein wall CSA, and umbilical artery wall CSA did not show any significant difference. Histological findings were edema (p < 0.001) and thickened basement membranes (p < 0.0001) were considered significant.

中文翻译：

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先兆子痫和正常妊娠脐带横截面的组织学和组织形态学：一项比较研究

摘要 脐带是连接母体和胎儿的纽带，其形态是胎儿健康的指标。先兆子痫是一种与新发高血压相关的妊娠疾病，最常发生在妊娠 20 周后。正常血压和高血压孕妇的脐带存在结构差异。本研究旨在研究先兆子痫脐带区域的组织学和组织形态计量学，并将参数与胎龄 37-40 周的正常无并发症妊娠进行比较。研究了来自先兆子痫 (n = 35) 和正常 (n = 35) 妊娠的总共 70 根脐带。研究的参数包括脐带横截面积 (CSA)、脐静脉腔、脐静脉壁、脐动脉腔、脐动脉壁、和沃顿氏胶，包括血管壁水肿和沃顿氏胶和基底膜增厚。先兆子痫的平均脐带 CSA 显着更高（p = 0.014）。平均脐动脉腔 CSA 显着低于正常妊娠脐带 (p = 0.006)。先兆子痫的平均沃顿果冻 CSA 显着高于正常妊娠脐带 (p = 0.004)。脐静脉腔 CSA、脐静脉壁 CSA 和脐动脉壁 CSA 的参数没有显示任何显着差异。组织学发现水肿（p < 0.001）和增厚的基底膜（p < 0.0001）被认为是显着的。先兆子痫的平均脐带 CSA 显着更高（p = 0.014）。平均脐动脉腔 CSA 显着低于正常妊娠脐带 (p = 0.006)。先兆子痫的平均沃顿果冻 CSA 显着高于正常妊娠脐带 (p = 0.004)。脐静脉腔 CSA、脐静脉壁 CSA 和脐动脉壁 CSA 的参数没有显示任何显着差异。组织学发现水肿（p < 0.001）和增厚的基底膜（p < 0.0001）被认为是显着的。先兆子痫的平均脐带 CSA 显着更高（p = 0.014）。平均脐动脉腔 CSA 显着低于正常妊娠脐带 (p = 0.006)。先兆子痫的平均沃顿果冻 CSA 显着高于正常妊娠脐带 (p = 0.004)。脐静脉腔 CSA、脐静脉壁 CSA 和脐动脉壁 CSA 的参数没有显示任何显着差异。组织学发现水肿（p < 0.001）和增厚的基底膜（p < 0.0001）被认为是显着的。脐静脉腔 CSA、脐静脉壁 CSA 和脐动脉壁 CSA 的参数没有显示任何显着差异。组织学发现水肿（p < 0.001）和增厚的基底膜（p < 0.0001）被认为是显着的。脐静脉腔 CSA、脐静脉壁 CSA 和脐动脉壁 CSA 的参数没有显示任何显着差异。组织学发现水肿（p < 0.001）和增厚的基底膜（p < 0.0001）被认为是显着的。