Background and objectives: Little is known regarding the diagnostic performance of fibrosis scoring systems in the diagnosis of nonalcoholic fatty liver disease (NAFLD). We aimed to determine the risk factors of NAFLD and evaluate the diagnostic performance of noninvasive fibrosis scoring systems.Materials and methods: The study included consecutive patients presented with dyspepsia from January 2017 to January 2019. Clinicodemographic and laboratory parameters including HOMA-IR were recorded. Anthropometric measurements were performed. NAFLD was diagnosed with ultrasonography. The FIB4, NAFLD, BARD, and Nippon scores were calculated.Results: Totally, 1008 patients were enrolled. The mean age was 52.3 ± 15 years in the NAFLD group (25.8%) and 36.7 ± 15.7 years in the non-NAFLD group (74.2%). The frequency of NAFLD was 25.8%. Age, body mass index (BMI), diabetes mellitus (DM), platelet count, HbA1c, HDL, ALT, and AST/ALT ratio were independent risk factors for NAFLD. The most sensitive and specific tests in diagnosing NAFLD were HOMA-IR and Nippon score, respectively.Conclusions: Age, BMI, DM, HbA1c, platelet count, HDL, ALT, and AST/ALT ratio were independent predictors of NAFLD. The most specific and sensitive predictors of the presence of NAFLD were Nippon score and HOMA-IR value, respectively. The place of fibrosis scores in the diagnosis of NAFLD patients requires further scrutinization.

中文翻译：

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非酒精性脂肪肝疾病的无创诊断：年龄和其他危险因素的影响。

背景和目的：关于纤维化评分系统在诊断非酒精性脂肪性肝病 (NAFLD) 中的诊断性能知之甚少。我们旨在确定 NAFLD 的危险因素并评估无创纤维化评分系统的诊断性能。材料和方法：该研究包括 2017 年 1 月至 2019 年 1 月连续出现消化不良的患者。记录临床人口统计学和实验室参数，包括 HOMA-IR。进行了人体测量。NAFLD 经超声检查确诊。计算FIB4、NAFLD、BARD和Nippon评分。结果：共纳入1008例患者。NAFLD 组的平均年龄为 52.3 ± 15 岁（25.8%），非 NAFLD 组的平均年龄为 36.7 ± 15.7 岁（74.2%）。NAFLD 的发生率为 25.8%。年龄，体重指数（BMI）、糖尿病（DM）、血小板计数、HbA1c、HDL、ALT和AST/ALT比值是NAFLD的独立危险因素。诊断NAFLD最敏感和特异的指标分别是HOMA-IR和Nippon评分。结论：年龄、BMI、DM、HbA1c、血小板计数、HDL、ALT和AST/ALT比值是NAFLD的独立预测因子。NAFLD 存在的最具体和最敏感的预测因子分别是 Nippon 评分和 HOMA-IR 值。纤维化评分在 NAFLD 患者诊断中的位置需要进一步审查。和 AST/ALT 比值是 NAFLD 的独立预测因子。NAFLD 存在的最具体和最敏感的预测因子分别是 Nippon 评分和 HOMA-IR 值。纤维化评分在 NAFLD 患者诊断中的位置需要进一步审查。和 AST/ALT 比值是 NAFLD 的独立预测因子。NAFLD 存在的最具体和最敏感的预测因子分别是 Nippon 评分和 HOMA-IR 值。纤维化评分在 NAFLD 患者诊断中的位置需要进一步审查。