ABSTRACT In this study, a quartz crystal microbalance (QCM) nanosensor was prepared to detect tryptophan. QCM nanosensor was prepared through the formation of tryptophan memories on the gold surface of QCM electrode using Methacryloylamidohistidine-Cu(II)-tryptophan ([MAH-Cu(II)]-tryptophan) pre-organised monomer system. The designed pre-organised monomer system was characterised by use of Fourier Transform Infrared (FTIR) and Atomic Force Microscope (AFM) was used to characterise the QCM nanosensors. After the characterisation studies, imprinted and non-imprinted sensors were connected to QCM system to determine the binding of the target molecule, selectivity and the detection of the amount of target molecule in real samples. The results showed that the imprinted QCM nanosensor had high selectivity for tryptophan. Graphical abstract

中文翻译：

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用于测定色氨酸的分子印迹聚合物基石英晶体微天平纳米传感器的开发

摘要 在本研究中，制备了一种石英晶体微天平 (QCM) 纳米传感器来检测色氨酸。QCM纳米传感器是通过使用甲基丙烯酰氨基组氨酸-Cu(II)-色氨酸([MAH-Cu(II)]-色氨酸)预组织单体系统在QCM电极的金表面形成色氨酸记忆来制备的。通过使用傅立叶变换红外 (FTIR) 和原子力显微镜 (AFM) 来表征设计的预组织单体系统，以表征 QCM 纳米传感器。表征研究后，将印迹和非印迹传感器连接到 QCM 系统，以确定目标分子的结合、选择性和实际样品中目标分子数量的检测。结果表明印迹QCM纳米传感器对色氨酸具有高选择性。图形概要