ABSTRACT

The fate of any cellular RNA is largely influenced by the nature and diversity of its interactions with various RNA-binding proteins (RBPs) leading to the formation of a biologically significant ribonucleoprotein (RNP) complex. La motif-containing proteins (composed of genuine La and La-related proteins (LARPs)) represent an evolutionary conserved family of RBPs that encompass a large range of crucial functions, involving coding and non-coding RNAs. In this work, we provide data that extend our previous knowledge on the distribution, organization and evolutionary history of this important protein family. Using a repertoire of 345 La motif-containing proteins from 135 species representing all major eukaryotic lineages, we were able to pinpoint many lineage-specific variations in the structural organization of La and LARPs and propose new evolutive scenarios to explain their modern genomic distribution.

摘要

任何细胞 RNA 的命运在很大程度上受其与各种 RNA 结合蛋白 (RBP) 相互作用的性质和多样性的影响，导致形成具有生物学意义的核糖核蛋白 (RNP) 复合物。含有 La 基序的蛋白质（由真正的 La 和 La 相关蛋白 (LARPs) 组成）代表了一个进化保守的 RBPs 家族，包含大量的关键功能，包括编码和非编码 RNA。在这项工作中，我们提供的数据扩展了我们之前关于这个重要蛋白质家族的分布、组织和进化历史的知识。使用来自代表所有主要真核细胞谱系的 135 个物种的 345 个含有 La 基序的蛋白质，