ABSTRACT The solubility of albendazole (ABZ) in a binary system of ethanol and water were determined experimentally by using a static analytical method within the temperature range (288.95 to 317.25) K under atmospheric pressure (p = 0.1 MPa). It was observed that the solubility of ABZ is not only depended on temperature but also related to the mole fraction of ethanol. Additionally, the obtained solubility data were correlated by employing the CNIBS/R-K model, the modified Apelblat equation and the Jouyban–Acree model. The modified Apelblat equation was proven to give good representation of the experimental solubility data. On the base of the measured solubility, the thermodynamic properties of the dissolution process were calculated. Dissolution of ABZ in these mixed solvents is endothermic, non-spontaneous and enthalpy-driving. This study provides useful information for the design and development of dosage forms of ABZ.

中文翻译：

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阿苯达唑在乙醇和水的二元溶剂中的溶解度和热力学性质的测定

摘要 阿苯达唑 (ABZ) 在乙醇和水的二元体系中的溶解度是通过使用静态分析方法在大气压 (p = 0.1 MPa) 的温度范围 (288.95 至 317.25) K 内通过实验确定的。观察到 ABZ 的溶解度不仅取决于温度，还与乙醇的摩尔分数有关。此外，通过使用 CNIBS/RK 模型、修正的 Apelblat 方程和 Jouyban-Acree 模型将获得的溶解度数据相关联。改进的 Apelblat 方程被证明可以很好地表示实验溶解度数据。在测量的溶解度的基础上，计算溶解过程的热力学性质。ABZ 在这些混合溶剂中的溶解是吸热的、非自发的和焓驱动的。