Abstract Synthesis of new 1,4-naphthoquinone derivatives is important in terms of searching new biologically active substances. In particular, compounds with piperazine and thiol moiety in their structure, show a wide range of pharmacological activity such as anti-inflammatory, anticancer, anti-fungal, anti-bacterial, anti-allergic, apoptosis and radical scavenging activities. In this study, new amino- and thio(substituted) naphthoquinone derivatives were synthesized by the reaction of thiols and thioalcohols with four naphthoquinone compounds which were used as starting materials. The new compounds were purified by column chromatography. The structure of the compounds was confirmed by different spectroscopic techniques. Graphical Abstract

中文翻译：

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新型氨基和硫代（取代）-1,4-萘醌 (NQ) 化合物：合成和表征

摘要 合成新的1,4-萘醌衍生物对于寻找新的生物活性物质具有重要意义。特别是，结构中含有哌嗪和硫醇部分的化合物显示出广泛的药理活性，如抗炎、抗癌、抗真菌、抗菌、抗过敏、细胞凋亡和自由基清除活性。在这项研究中，通过硫醇和硫醇与四种用作起始原料的萘醌化合物反应，合成了新的氨基和硫代（取代）萘醌衍生物。新化合物通过柱色谱纯化。通过不同的光谱技术确认了化合物的结构。图形概要