Abstract

Trillium govanianum, commonly known as Nag Chhatri and Teen Patra, is a popular herbal supplement traditionally used for curing different inflammatory and sexual disorders, infection and wound healing. Steroidal saponins are considered as active components of this species. The present study demonstrated the isolation of nine steroidal saponins, including one new compound named as govanoside B (9) and eight known, pregna-chacotrioside (1), pennogenin-triglycoside (2), borassoside E (3), pennogenin-tetraglycoside (4), protodioscin (5), clintonioside B (6), pennogenin-diglycoside (7) and borassoside D (8). This is the first report on the isolation of 1, 2, 4, 5, 6, 7 and 8 from rhizomes of T. govanianum. The extract, fractions and isolated compounds were further evaluated for their DPPH and ABTS radical scavenging activity.

摘要

Trillium govanianum，通常被称为 Nag Chhatri 和 Teen Patra，是一种流行的草药补充剂，传统上用于治疗不同的炎症和性障碍、感染和伤口愈合。甾体皂苷被认为是该物种的活性成分。本研究证明了九种甾体皂苷的分离，其中包括一种新的化合物，命名为 govanoside B ( 9 ) 和八种已知化合物，pregna-chacotrioside ( 1 )、pennogenin-triglycoside ( 2 )、borassoside E ( 3 )、pennogenin-tetraglycoside ( 4 )、原薯蓣皂苷( 5 )、克林酮苷B( 6 )、青蒿素-二糖苷( 7 )和硼酸硼苷D( 8 )）。这是第一次从T. govanianum的根茎中分离出1、2、4、5、6、7和8的报道。进一步评估提取物、级分和分离的化合物的 DPPH 和 ABTS 自由基清除活性。