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Preparation and Degradation Behaviors of Poly(L-lactide-co-glycolide-co-ε-caprolactone)/1,4-butanediamine Modified Poly(lactic-co-glycolic acid) Blend Film
Journal of Macromolecular Science Part B-Physics ( IF 1.4 ) Pub Date : 2020-04-07 , DOI: 10.1080/00222348.2020.1746027
Ziwei Zhou 1 , Zhihua Zhou 1, 2, 3 , Wenjuan Liu 2 , Tianlong Huang 4 , Yanmin Zhao 1 , Ping Chen 1 , Dan Wang 1 , Jianjun Fang 1
Affiliation  

Polymer blending is an attractive method for producing new polymer materials with excellent properties. In this work the blended polymers were prepared from poly(L-lactide-co-glycolide-co-ε-caprolactone) and 1,4-butanediamine modified poly(lactic-co-glycolic acid) (PLLGC/BMPLGA). The hydrophilicity was studied by static water contact angle tests. The in-vitro degradation behaviors of the PLLGC/BMPLGA blended films were investigated during various degradation periods. The results showed that the introduction of the PLLGC reduced the hydrophilicity and degradation rate of the blended polymers while improved the tensile strength and elongation percentage. Therefore, we suggest the blends of the PLLGC and BMPLGA could supply a potential biomaterial for application in the medical field for use as tissue engineering scaffolds or drug delivery.



中文翻译:

聚(L-丙交酯-乙交酯-ε-己内酯)/ 1,4-丁二胺改性聚乳酸​​-乙醇酸共混膜的制备及降解行为

聚合物共混是生产具有优异性能的新型聚合物材料的一种有吸引力的方法。在这项工作中,共混聚合物是由聚(L-丙交酯-乙交酯-共-ε-己内酯)和1,4-丁二胺改性的聚(乳酸-乙醇酸)(PLLGC / BMPLGA)制备的。通过静态水接触角测试研究了亲水性。研究了PLLGC / BMPLGA共混膜在不同降解期间的体外降解行为。结果表明,PLLGC的引入降低了共混聚合物的亲水性和降解率,同时提高了拉伸强度和伸长率。因此,我们建议PLLGC和BMPLGA的共混物可以为医疗领域提供潜在的生物材料,用作组织工程支架或药物输送。

更新日期:2020-04-07
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