Abstract Impregnated thin-layer chromatography (TLC) layers based on silica gel are presented. Impregnating agents such as metal cations, inorganic ions, chelating agents, chiral selectors, surfactants, ion-pairing reagents, and ionic liquids are discussed. The role of impregnated TLC layers in medicinal chemistry is highlighted. The historical overview of TLC separations on physically coated layers is given and some future prospects ahead of this technique are discussed. GRAPHICAL ABSTRACT

中文翻译：

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薄层色谱中的浸渍硅胶层

摘要 介绍了基于硅胶的浸渍薄层色谱 (TLC) 层。讨论了浸渍剂，例如金属阳离子、无机离子、螯合剂、手性选择剂、表面活性剂、离子对试剂和离子液体。强调了浸渍 TLC 层在药物化学中的作用。给出了物理涂层上 TLC 分离的历史概述，并讨论了该技术之前的一些未来前景。图形概要