ABSTRACT Geraniol presents many pharmacological properties including antifungal and antibacterial activity. The objective of this study was to conduct a review of the literature concerning in vitro antimicrobial activity, anti-biofilm action, and association studies with drugs and geraniol. The study was based on a literature search from 2007 to 2019, in the databases Lilacs, Scielo, Science Direct, and PubMed. The results of 21 articles 8were selected where the most studied genera were Candida and Staphylococcus. Broth microdilution methods were the most frequently used and generally presented MIC values of ≤600 µg/mL. In the association studies, the most used technique was Checkerboard, where combinations of geraniol and standard antimicrobials were found to be synergic for most strains. Geraniol also showed antibiotic activity against the genus Staphylococcus. From our review results, it is clear that the phytoconstituent geraniol presents antimicrobial action against various species.

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香叶醇的抗菌活性：综合评价

摘要 香叶醇具有许多药理特性，包括抗真菌和抗菌活性。本研究的目的是对有关体外抗菌活性、抗生物膜作用以及与药物和香叶醇的关联研究的文献进行综述。该研究基于 2007 年至 2019 年在 Lilacs、Scielo、Science Direct 和 PubMed 数据库中的文献检索。结果共筛选出21篇文献8，其中研究最多的属为念珠菌属和葡萄球菌属。肉汤微量稀释方法是最常用的方法，通常其 MIC 值≤600 µg/mL。在关联研究中，最常用的技术是棋盘格，发现香叶醇和标准抗菌剂的组合对大多数菌株具有协同作用。香叶醇还显示出对葡萄球菌属的抗生素活性。从我们的审查结果来看，很明显，植物成分香叶醇对各种物种都具有抗菌作用。