Abstract

Long noncoding RNAs (lncRNAs) are a large class of non (protein)-coding RNAs, which are longer beyond 200 nucleotides. LncRNA GAS5 is widely considered as a tumour suppressor in cell proliferation, apoptosis, cell migration and invasion of tumour cells. Recently, a growing body of evidences indicated that GAS5 was also widely involved in the pathologic process of cardiovascular cells, including regulation of apoptosis and inflammatory injury of cardiomyocytes; proliferation, apoptosis, autophagy and angiogenesis of endothelial cells; and proliferation, migration, apoptosis and differentiation of VSMCs. In this regard, we summarised current studies of GAS5 in cardiovascular cells, which shed light on not only our understanding of the mechanisms of GAS5 in cardiovascular cells but also understanding of the potential of GAS5 as novel therapeutic target.

摘要

长链非编码 RNA (lncRNA) 是一大类非（蛋白质）编码 RNA，长度超过 200 个核苷酸。LncRNA GAS5被广泛认为是细胞增殖、凋亡、细胞迁移和肿瘤细胞侵袭的抑癌基因。最近，越来越多的证据表明，GAS5也广泛参与心血管细胞的病理过程，包括调节心肌细胞的凋亡和炎症损伤；内皮细胞的增殖、凋亡、自噬和血管生成；VSMCs 的增殖、迁移、凋亡和分化。在这方面，我们总结了当前心血管细胞中 GAS5 的研究，