Abstract A series of triorganotin(IV) compounds {Me3SnL (1), Bu3SnL (2), Ph3SnL (3)} and di-organotin(IV) complexes {Me2SnL2 (4), Bu2SnL2 (5) and Ph2SnL2 (6)}, where Me = methyl, Bu = butyl, Ph = phenyl and L = 2-(1H-indole-3-yl)acetate) have been synthesized and characterized by FT-IR and multinuclear NMR (1H-, 13C- and 119Sn-NMR) spectroscopy. Tri- and diorganotin(IV) derivatives exhibited five- and six-coordinate geometries, respectively, in solid state as evident from the Δν value. Five-coordinate trigonal bipyramidal and six-coordinate octahedral geometry was assigned to 1 and 4 in solution state based on NMR data as evident from 2J(119Sn,1H) and 1J(119Sn-13C) coupling constant values, which was further attested by 119Sn NMR. Single crystal XRD analysis on 1 revealed that it exhibited polymeric crystal structure with distorted trigonal bipyramidal geometry around the tin center with two unequal Sn–O bonds. The screening of the synthesized compounds for cytotoxicity showed good activity in comparison to cis-platin. They have also displayed moderate to good antimicrobial activities. Graphical Abstract

中文翻译：

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新的三和二烷基甲锡烷基 2-(1H-indol-3-yl) 乙酸酯：合成、表征和生物筛选

摘要 一系列三有机锡(IV)化合物{Me3SnL(1)、Bu3SnL(2)、Ph3SnL(3)}和二有机锡(IV)配合物{Me2SnL2(4)、Bu2SnL2(5)和Ph2SnL2(6)}，其中 Me = 甲基，Bu = 丁基，Ph = 苯基，L = 2-(1H-indole-3-yl)acetate) 已合成并通过 FT-IR 和多核 NMR（1H-、13C-和 119Sn-NMR）表征) 光谱学。从 Δν 值可以明显看出，三和二有机锡 (IV) 衍生物在固态下分别表现出五坐标和六坐标几何形状。根据核磁共振数据，从 2J(119Sn,1H) 和 1J(119Sn-13C) 耦合常数值明显看出，五坐标三角双锥和六坐标八面体几何在溶液状态下被指定为 1 和 4，119Sn 进一步证明了这一点核磁共振。对 1 的单晶 XRD 分析表明，它表现出聚合物晶体结构，在锡中心周围具有扭曲的三角双锥几何形状，具有两个不等的 Sn-O 键。与顺铂相比，对合成化合物的细胞毒性筛选显示出良好的活性。它们还显示出中等至良好的抗微生物活性。图形概要