Abstract

Two new tremulane-type sesquiterpenes, irlactin L (1) and irlactin M (2) were isolated from cultures of the fungus Irpex lacteus, together with one known compound, 6-hydroxy-2,6-dimethyloct-7-enoic acid (3). Their structures were elucidated by spectroscopic data analysis. Compounds 1–2 were tested for their cytotoxicities against five human cancer cell lines and for their inhibitory activities against isozymes of 11β-hydroxysteroid dehydrogenases (11β-HSD).

中文翻译：

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两种来自真菌Irpex lacteus培养物的新倍半萜

摘要

从真菌Irpex lacteus的培养物中分离出两种新的tremulane型倍半萜，irlactin L（1）和irlactin M（2），以及一种已知的化合物6-羟基-2,6-二甲基辛7-烯酸（3）。通过光谱数据分析阐明了它们的结构。化合物1-2它们对5个人癌细胞系的细胞毒活性和它们的抑制活性进行了测试对的11个同工酶β羟基类固醇脱氢酶（11 β -HSD）。