Abstract

Two new phenolic glycosides (1-2), along with six existing compounds (3-8), were isolated from the ethanolic extract of Ilex pubescens roots, a traditional folk medicine. These structures were determined using HR-ESI-MS, IR, UV, and NMR (including 1 D, 2 D-NMR). The anti-inflammatory activities of three phenolic glycosides (1-3) were evaluated in the human HepG2 cell lines. The results showed that compound 3 could induce P-gp and BCRP expression through the Nrf2-mediated pathway.

中文翻译：

---

毛白杨QR，来自毛冬青的两种新的酚类糖苷

摘要

从传统民药冬青根的乙醇提取物中分离出两个新的酚类糖苷（1-2）和六个现有化合物（3-8）。这些结构是使用HR-ESI-MS，IR，UV和NMR（包括1 D，2 D-NMR）确定的。在人类HepG2细胞系中评估了三种酚类糖苷（1-3）的抗炎活性。结果表明，化合物3可通过Nrf2介导的途径诱导P-gp和BCRP表达。