Abstract

A new flavonoid named saniculamin C (1), together with six known compounds (2-7), were isolated from the whole plants of Sanicula lamelligera Hance. The chemical structures were elucidated by spectroscopic and physico-chemical analyses. All isolates were evaluated for in vitro cytotoxic activities against four human cancer cell lines, HepG2, SGC-7901 gastric cancer, Hela and A-549 lung cancer. Compound 1 showed potent antiproliferative activities against SGC-7901 cells with IC₅₀ value of 7.45 μM. In addition, compound 6 exhibited weak antiproliferative activities against HepG2, SGC-7901, Hela cancer cells with IC₅₀ values of 10.43, 8.24 and 15.32 μM, respectively.

摘要

从Sanicula lamelligera Hance的整个植物中分离到一种新的类黄酮，名为saniculamin C（1）和六个已知化合物（2-7）。通过光谱和物理化学分析阐明了化学结构。评估了所有分离物对四种人类癌细胞系HepG2，SGC-7901胃癌，Hela和A-549肺癌的体外细胞毒性活性。化合物1对SGC-7901细胞显示出有效的抗增殖活性，IC ₅₀值为7.45μM。此外，化合物6对带有IC _50的HepG2，SGC-7901和Hela癌细胞均显示出弱的抗增殖活性 分别为10.43、8.24和15.32μM。