Abstract

Two new chlorophenolic glucosides curculigines P (1) and Q (2), together with seven known compounds (3–9), were isolated from the dried rhizomes of Curculigo orchioides. Their structures were determined by spectroscopic methods including 1 D, 2 D NMR and MS. All the isolated compounds were evaluated on 5α-reductase activity by a HaCaT-based bioassay. Compounds 1–9 showed varying degrees of inhibiting activity against 5α-reductase, while compound 1 indicated the most potent inhibitory effect.

中文翻译：

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兰茅草中的新氯酚苷及其对5α-还原酶的活性

摘要

从干燥的Curculigo orchioides的根茎中分离出两种新的氯酚苷姜黄素P（1）和Q（2），以及七个已知化合物（3-9）。通过包括1 D，2 D NMR和MS在内的光谱方法确定了它们的结构。通过基于HaCaT的生物测定法评估所有分离的化合物的5α-还原酶活性。化合物1–9对5α-还原酶表现出不同程度的抑制活性，而化合物1显示最有效的抑制作用。