ABSTRACT

Present studies on serum hepcidin levels in patients with rheumatoid arthritis (RA) are inconsistent. We aimed to synthetically evaluate the relationship between hepcidin and RA, and the correlation of serum hepcidin levels and RA disease activity as well as anemia associated with RA. Multiple electronic databases were searched. Pooled standard mean difference (SMD) with 95% confidence interval (CI) and correlation coefficients between hepcidin levels and rheumatoid factor (RF), disease activity for 28 joints (DAS28), and erythrocyte sedimentation rate (ESR) were calculated. Totally, 13 articles were available for this meta-analysis. The results revealed that serum levels of hepcidin were higher in RA patients compared to healthy controls (SMD = 0.573, 95% CI = 0.317 to 0.829, p < .001); RA patients with anemia had higher serum hepcidin levels than RA patients without anemia (SMD = 0.400, 95% CI = 0.080 to 0.720, p = .014); RA patients with pure ACD had higher serum hepcidin levels than RA patients with ACD and IDA (SMD = 0.658, 95% CI = 0.018 to 1.299, p = .044). Moreover, the result of correlation coefficients identified a significant positive correlation between hepcidin levels and RF, DAS28 as well as ESR. Serum hepcidin levels may be closely associated with the development of RA.

摘要

目前关于类风湿性关节炎 (RA) 患者血清铁调素水平的研究并不一致。我们旨在综合评估铁调素与 RA 之间的关系，以及血清铁调素水平与 RA 疾病活动度以及与 RA 相关的贫血的相关性。搜索了多个电子数据库。计算了具有 95% 置信区间 (CI) 的合并标准平均差 (SMD) 以及铁调素水平与类风湿因子 (RF)、28 个关节的疾病活动性 (DAS28) 和红细胞沉降率 (ESR) 之间的相关系数。共有 13 篇文章可用于该荟萃分析。结果显示，与健康对照组相比，RA 患者的血清铁调素水平更高（SMD = 0.573，95% CI = 0.317 至 0.829，p < .001）；有贫血的 RA 患者的血清铁调素水平高于无贫血的 RA 患者（SMD = 0.400，95% CI = 0.080 至 0.720，p = .014）；患有纯 ACD 的 RA 患者的血清铁调素水平高于患有 ACD 和 IDA 的 RA 患者（SMD = 0.658，95% CI = 0.018 至 1.299，p = .044）。此外，相关系数的结果确定了铁调素水平与 RF、DAS28 以及 ESR 之间的显着正相关。血清铁调素水平可能与 RA 的发展密切相关。DAS28 以及 ESR。血清铁调素水平可能与 RA 的发展密切相关。DAS28 以及 ESR。血清铁调素水平可能与 RA 的发展密切相关。