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Low hydration status may be associated with insulin resistance and fat distribution: analysis of the Korea National Health and Nutrition Examination Survey (KNHANES) 2008–2010
British Journal of Nutrition ( IF 3.6 ) Pub Date : 2020-03-19 , DOI: 10.1017/s0007114520001063 Hyang K Min 1 , Hyun Y Ko 1 , Jin T Kim 1 , Lise Bankir 2 , Sung W Lee 1
British Journal of Nutrition ( IF 3.6 ) Pub Date : 2020-03-19 , DOI: 10.1017/s0007114520001063 Hyang K Min 1 , Hyun Y Ko 1 , Jin T Kim 1 , Lise Bankir 2 , Sung W Lee 1
Affiliation
We aimed to identify the association of hydration status with insulin resistance (IR) and body fat distribution. A total of 14 344 adults participated in the Korea National Health and Nutrition Examination Survey 2008–2010. We used urine specific gravity (USG) to indicate hydration status, and HOMA-IR (homoeostasis model assessment of IR) and trunk:leg fat ratio (TLR) as primary outcomes. In multivariate logistic regression, the OR per 0·01 increase in USG for high IR was 1·303 (95 % CI 1·185, 1·433; P < 0·001). In multivariate generalised additive model plots, increased USG showed a J-shaped association with logarithmic HOMA-IR, with the lowest Akaike’s information criterion score of USG 1·030. Moreover, increased USG was independently associated with increased trunk fat, decreased leg fat and increased TLR. In mediation analysis, the proportion of mediation effects of USG on TLR via IR was 0·193 (95 % CI 0·132, 0·285; P < 0·001), while the proportion of mediation effects of USG on IR via TLR was 0·130 (95 % CI 0·086, 0·188; P < 0·001). Increased USG, a sign of low hydration status and presumably high vasopressin, was associated with IR and poor fat distribution. Direct effect of low hydration status may be more dominant than indirect effect via IR or fat distribution. Further studies are necessary to confirm our findings.
中文翻译:
低水合状态可能与胰岛素抵抗和脂肪分布有关:2008-2010 年韩国国民健康和营养检查调查 (KNHANES) 的分析
我们的目的是确定水合状态与胰岛素抵抗 (IR) 和体脂分布之间的关联。共有 14 344 名成年人参加了 2008-2010 年韩国国民健康和营养检查调查。我们使用尿比重 (USG) 来指示水合状态,并使用 HOMA-IR(IR 稳态模型评估)和躯干:腿部脂肪比 (TLR) 作为主要结果。在多变量逻辑回归中,对于高 IR,USG 每增加 0·01 的 OR 为 1·303(95% CI 1·185,1·433;P < 0·001)。在多变量广义加性模型图中,增加的 USG 与对数 HOMA-IR 呈 J 形关联,最低 Akaike 的信息标准得分为 USG 1·030。此外,USG 增加与躯干脂肪增加、腿部脂肪减少和 TLR 增加独立相关。在中介分析中,USG 通过 IR 对 TLR 的中介作用比例为 0·193 (95 % CI 0·132, 0·285;P < 0·001),而 USG 通过 TLR 调节 IR 的比例为 0·130 (95 % CI 0·086, 0·188;P < 0·001)。增加的 USG 是低水合状态和可能高加压素的标志,与 IR 和脂肪分布不良有关。低水合状态的直接影响可能比通过 IR 或脂肪分布的间接影响更显着。需要进一步的研究来证实我们的发现。
更新日期:2020-03-19
中文翻译:
低水合状态可能与胰岛素抵抗和脂肪分布有关:2008-2010 年韩国国民健康和营养检查调查 (KNHANES) 的分析
我们的目的是确定水合状态与胰岛素抵抗 (IR) 和体脂分布之间的关联。共有 14 344 名成年人参加了 2008-2010 年韩国国民健康和营养检查调查。我们使用尿比重 (USG) 来指示水合状态,并使用 HOMA-IR(IR 稳态模型评估)和躯干:腿部脂肪比 (TLR) 作为主要结果。在多变量逻辑回归中,对于高 IR,USG 每增加 0·01 的 OR 为 1·303(95% CI 1·185,1·433;