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Nano-hydroxyapatite use in dentistry: a systematic review.
Drug Metabolism Reviews ( IF 5.9 ) Pub Date : 2020-05-12 , DOI: 10.1080/03602532.2020.1758713
Ioana Roxana Bordea 1 , Sebastian Candrea 2 , Gabriela Teodora Alexescu 3 , Simion Bran 4 , Mihaela Băciuț 4 , Grigore Băciuț 5 , Ondine Lucaciu 1 , Cristian Mihail Dinu 5 , Doina Adina Todea 5, 6
Affiliation  

Nano-hydroxyapatite (nano-HA) is a material with multiple uses due to its biocompatibility and its resemblance to the nonorganic bone structure. It is used in various dental domains such as implantology, surgery, periodontology, esthetics and prevention. The aim of this study is to provide a wide understanding of nano-HA and to promote treatments based on nanomaterials in dentistry. A search in two data bases, Scopus, and PubMED, was conducted over a 5 years period. We chose a 5 years period because this revealed the most recent published studies with the key words 'nano-HA' and 'dentistry'. A number of 32 studies were included in this systematic review. In implantology the main use of nano-HA was as a coating material for titanium implants and its effect was assessed in the matter of osteointegration and inflammatory response as well as antibacterial activity. In tissue engineering the use of nano-HA was directed to surgery and periodontology and this material was assessed mainly as a grafting material. In esthetics and prevention its use was mainly focused on dentinal hypersensitivity treatment, remineralizing potential and as bleaching co-agent. Nano-HA is a relatively novel material with outstanding physical, chemical, mechanical and biological properties that makes it suitable for multiple interventions. It outperformed most of the classic materials used in implantology and surgery but it should be further investigated for bone engineering and caries prevention therapy.

中文翻译:

纳米羟基磷灰石在牙科中的应用:系统综述。

纳米羟基磷灰石(nano-HA)是一种具有多种用途的材料,因为它具有生物相容性并且与非有机骨结构相似。它被用于各种牙科领域,例如种植学,手术,牙周病,美学和预防。这项研究的目的是提供对纳米HA的广泛理解,并促进基于纳米材料的牙科治疗。在5年的时间内对两个数据库Scopus和PubMED进行了搜索。我们选择了5年的时间,因为这揭示了最新发表的关键词为“ nano-HA”和“牙科”的研究。该系统评价包括32项研究。在植入术中,纳米HA的主要用途是作为钛植入物的涂层材料,并在骨整合和炎症反应以及抗菌活性方面评估了其效果。在组织工程中,纳米HA的用途直接用于手术和牙周病,并且该材料主要被评估为移植材料。在美学和预防方面,其使用主要集中在牙本质过敏治疗,再矿化潜力和作为漂白助剂。Nano-HA是一种相对新颖的材料,具有出色的物理,化学,机械和生物学特性,使其适用于多种干预。它的性能优于大多数用于移植术和外科手术的经典材料,但应进一步研究其在骨工程和龋齿预防治疗中的作用。
更新日期:2020-05-12
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