Chronic obstructive pulmonary disease (COPD) is a heterogeneous entity with different clinical phenotypes, such as asthma-COPD overlap (ACO). The aim of this retrospective study was to compare routine blood biomarkers in patients with ACO and the remaning COPD phenotypes. Data were collected from stable COPD patients visited in during 2018, including C-reactive protein (CRP), fibrinogen, neutrophyl/lymphocyte ratio (NLR) and platelet/lymphocyte ratio (PLR).A total of 77 patients with COPD were included, 24 (31%) fulfilled the diagnosis of ACO. Clinically, patients with ACO presented more dyspnoea and wheezing. Regarding laboratory parameters, both groups had low levels of lymphocytes, especially the non-ACO group (24.2% vs. 29.3%; p = 0.031), patients with ACO had significantly higher eosinophil counts (4.7% vs. 1.9%; p < 0.001) but a lower percentage of neutrophils (56.8% vs. 64.7%; p = 0.003), NLR and PLR (2.5 vs. 3.8; p = 0.013 and 115 vs. 160; p = 0.063, respectively). In conclusion, besides the expected eosinophilic inflammation in patients with ACO, both groups had low levels of lymphocytes, especially the non-ACO group. The low levels of lymphocytes, in particular in non-ACO patients, should be confirmed in larger studies.

慢性阻塞性肺疾病 (COPD) 是具有不同临床表型的异质实体，例如哮喘-COPD 重叠 (ACO)。这项回顾性研究的目的是比较 ACO 和剩余 COPD 表型患者的常规血液生物标志物。数据来自2018年就诊的稳定COPD患者，包括C反应蛋白（CRP）、纤维蛋白原、中性粒细胞/淋巴细胞比值（NLR）和血小板/淋巴细胞比值（PLR）。共纳入77例COPD患者，24例(31%) 符合 ACO 的诊断。临床上，ACO患者出现更多的呼吸困难和喘息。关于实验室参数，两组的淋巴细胞水平均较低，尤其是非 ACO 组（24.2% 对 29.3%；p = 0.031)，ACO 患者的嗜酸性粒细胞计数显着较高（4.7% 对 1.9%；p  < 0.001），但中性粒细胞百分比较低（56.8% 对 64.7%；p  = 0.003）、NLR 和 PLR（2.5 对3.8；分别为p  = 0.013 和 115 与 160；p  = 0.063）。总之，除了 ACO 患者预期的嗜酸性炎症外，两组的淋巴细胞水平都较低，尤其是非 ACO 组。淋巴细胞水平低，特别是在非 ACO 患者中，应在更大的研究中得到证实。