Abstract Silicon particles in combination with the dynamic nuclear polarization (DNP) method have recently attracted attention as promising biomedical platforms for drug delivery and medical diagnostics in magnetic resonance spectroscopy (MRS) and MR imaging (MRI). In the present review, silicon particles were investigated as potential diagnostic probes for 29Si MRI to research in vivo and in vitro diverse bimolecular processes. Hyperpolarization characteristics of silicon particles based on their size, morphology, and physicochemical properties, were broadly demonstrated. Moreover, in vivo applications with the hyperpolarized silicon materials indicate the potential of the new diagnostic platform and will be of significant value for early diagnosis of diseases, including cancer.

中文翻译：

---

硅粒子在超极化29Si磁共振成像中的应用与展望

摘要 硅粒子与动态核极化 (DNP) 方法相结合，作为用于药物输送和磁共振波谱 (MRS) 和磁共振成像 (MRI) 医学诊断的有前途的生物医学平台，最近引起了人们的关注。在本综述中，研究了硅颗粒作为 29Si MRI 的潜在诊断探针，以研究体内和体外的多种双分子过程。广泛证明了基于硅颗粒的尺寸、形态和物理化学特性的超极化特性。此外，超极化硅材料的体内应用表明了新诊断平台的潜力，并将对包括癌症在内的疾病的早期诊断具有重要价值。