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UK case control study of smoking and risk of amyotrophic lateral sclerosis
Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration ( IF 2.8 ) Pub Date : 2020-04-17 , DOI: 10.1080/21678421.2019.1706580
Sarah Opie-Martin 1 , Ashley Jones 1 , Alfredo Iacoangeli 1 , Ahmad Al-Khleifat 1 , Mohamed Oumar 1 , Pamela J. Shaw 2 , Chris E. Shaw 1 , Karen E. Morrison 3 , Robyn E. Wootton 4, 5, 6 , George Davey-Smith 4 , Neil Pearce 7 , Ammar Al-Chalabi 5
Affiliation  

Abstract

Introduction: Susceptibility to amyotrophic lateral sclerosis (ALS) is associated with smoking in some studies, but it is not clear which aspect of smoking behavior is related. Using detailed records of lifetime smoking we investigated the relationship between smoking and ALS in a UK population. Methods: In this retrospective case-control study, smoking status was collected using environmental questionnaires from people diagnosed with ALS between 2008 and 2013 and from age, sex and geographically matched controls. Categorical measures of smoking behavior were: smoking at the time of survey and smoking initiation; continuous measures were intensity (cigarettes per day), duration (years from starting to stopping or time of survey), cigarette pack years, and comprehensive smoking index (CSI), a measure of lifetime smoking. We used logistic regression to assess the risk of ALS with different combinations of smoking variables adjusted for age at survey, gender, level of education, smoking status and alcohol initiation, selecting the best model using the Akaike Information Criterion. Results: There were 388 records with full smoking history. The best-fitting model used CSI and smoking status at the time of survey. We found a weak association between current smoking and risk of ALS, OR 3.63 (95% CI 1.02–13.9) p value 0.05. Increase in CSI score did not increase risk of ALS: OR 0.81 (95% CI 0.58–1.11) p value 0.2.Conclusion: There is weak evidence of a positive effect of current smoking on the risk of ALS which does not show dose-dependence with higher levels of lifetime smoking and maybe a false positive result.



中文翻译:

英国吸烟与肌萎缩性侧索硬化症风险的病例对照研究

摘要

简介:在某些研究中,肌萎缩性侧索硬化症(ALS)的易感性与吸烟有关,但尚不清楚吸烟行为的哪个方面与吸烟有关。使用一生吸烟的详细记录,我们调查了英国人群中吸烟与ALS之间的关系。方法:在这项回顾性病例对照研究中,使用环境调查表收集了2008年至2013年之间被诊断为ALS的人以及年龄,性别和地理位置相符的对照者的吸烟状况。吸烟行为的分类指标是:调查时和吸烟开始时的吸烟情况;连续性指标包括强度(每天抽烟),持续时间(从开始到停止吸烟的年限或调查时间),香烟包装年限以及全面吸烟指数(CSI),这是一生的吸烟量度。我们使用逻辑回归来评估吸烟风险的不同组合,该变量根据调查的年龄,性别,受教育程度,吸烟状况和酗酒情况调整了吸烟变量的不同组合,并使用Akaike信息准则选择了最佳模型。结果:有388条完整吸烟史的记录。最适合的模型在调查时使用CSI和吸烟状况。我们发现当前吸烟与ALS风险之间存在弱关联,即3.63(95%CI 1.02-13.9)p值0.05。CSI评分的增加并未增加ALS的风险:OR 0.81(95%CI 0.58–1.11)p值0.2。结论:很少有证据表明当前吸烟对ALS的风险具有积极作用,但与终生吸烟水平较高没有剂量依赖性,并且可能有假阳性结果。

更新日期:2020-04-17
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