The grape skins after pressing the juice are a major problem for winery. However, because it contains a large amount of polyphenols, development of effective usages are expected to construct sustainable waste use. In this study, we examined whether grape skin extract is effective for recovery of DNA damage caused by UV irradiation. Extract from Zweigelt and Niagara skin was prepared by methanol, and UV irradiation was performed at 10 mJ/cm² (250 nm) and 15 mJ/cm² (290 nm) using human normal skin cells. As results, the decreased cell viability due to UV irradiation was improved by adding Niagara or Zweigelt skin extract. On the other hand, cyclobutane pyrimidine dimer production due to UV irradiation decreased significantly by Niagara or Zweigelt extract. In addition, the effects of grape skin extracts on the expression of sirtuin gene were also examined.

榨汁后的葡萄皮是酿酒厂的主要问题。但是，由于它含有大量的多酚，有效利用的发展有望促进可持续的废物利用。在这项研究中，我们检查了葡萄皮提取物是否对恢复紫外线辐射引起的DNA损伤有效。用甲醇制备茨维格特和尼亚加拉皮肤的提取物，并以10 mJ / cm ²（250 nm）和15 mJ / cm ²进行紫外线照射（290 nm）使用人类正常的皮肤细胞。结果，通过添加Niagara或Zweigelt皮肤提取物改善了由于UV辐射引起的细胞活力降低。另一方面，Niagara或Zweigelt提取物由于紫外线照射而导致的环丁烷嘧啶二聚体的产量显着下降。此外，还检查了葡萄皮提取物对sirtuin基因表达的影响。