Process safety testing performed on a batch process for making a pharmaceutical intermediate revealed that one process stream, a reaction in dimethyl sulfoxide, had a significant undesired reaction that could lead to catastrophic vessel failure as a result of a single process deviation. Comprehensive testing identified the worst case process stream with the lowest exotherm initiation temperature and most severe pressure consequences, for which corrective actions must be taken. With this information in hand, hazard assessments were performed to support processing, to determine the appropriate safeguards needed to mitigate the consequences, and to reduce the likelihood of reaching this activity to a tolerable level.

中文翻译：

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案例研究——表征和避免二甲基亚砜反应发生灾难性容器故障的风险

对用于制造医药中间体的批量工艺进行的工艺安全测试表明，一个工艺流，即在二甲亚砜中的反应，发生了显着的不希望有的反应，由于单个工艺偏差，可能导致灾难性的容器故障。 .. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 综合测试确定了具有最低放热起始温度和最严重压力后果的最坏情况工艺流，必须对其采取纠正措施。有了这些信息，我们就可以进行危害评估以支持处理，确定减轻后果所需的适当保护措施，并将达到此活动的可能性降低到可容忍的水平。