We sought to determine if Parkinson’s disease (PD) with mild cognitive impairment (MCI) is associated with a greater SERIAL‐ORDER (mental manipulation) than ANY‐ORDER (auditory span, storage) deficit in working memory (WM). We investigated WM combining neuropsychological measures with the study of brain functional connectivity. A cohort of 160 patients with idiopathic PD, classified as PD‐MCI (n = 87) or PD with normal cognition (PD‐NC; n = 73), and 70 matched healthy controls were studied. Verbal WM was assessed with the Backward Digit Span Task (BDT; Lamar et al., 2007, Neuropsychologia, 45, 245), measuring SERIAL‐ORDER and ANY‐ORDER recall. Resting‐state MRI data were collected for 15 PD‐MCI, 15 PD‐NC and 30 controls. Hypothesis‐driven seed‐based functional connectivity of the dorsolateral prefrontal cortex (DLPFC) was compared between the three groups and correlated with BDT performance. We found the main effect of the test (impairment in SERIAL ORDER > ANY ORDER) and group ((NC = PD‐NC) > PD‐MCI) in BDT performance that was even more pronounced in SERIAL ORDER when controlling for ANY ORDER variability but not vice versa. Furthermore, PD‐MCI compared to other groups were characterized by the functional disconnection between the bilateral DLPFC and the cerebellum. In functional correlations, DLPFC connectivity was positively related to both SERIAL‐ and ANY‐ORDER performance. In conclusion, PD‐MCI patients evidenced greater SERIAL‐ORDER (manipulation and cognitive control) than ANY‐ORDER (storage) working memory impairment than PD‐NC and controls with a disrupted DLPFC resting‐state connectivity that was also related to the verbal WM performance.

中文翻译：

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帕金森病认知谱中工作记忆中的序列顺序回忆与神经影像学相关

我们试图确定具有轻度认知障碍 (MCI) 的帕金森病 (PD) 是否与工作记忆 (WM) 的任何顺序 (听觉跨度、存储) 缺陷相比，与更大的串行顺序 (精神操纵) 相关。我们将神经心理学测量与大脑功能连接研究相结合，对 WM 进行了调查。研究了 160 名被分类为 PD-MCI（n  = 87）或认知正常的 PD（PD-NC；n  = 73）的特发性 PD 患者和 70 名匹配的健康对照的队列。使用 Backward Digit Span Task (BDT; Lamar et al., 2007, Neuropsychologia, 45, 245)，测量 SERIAL-ORDER 和 ANY-ORDER 召回。收集了 15 名 PD-MCI、15 名 PD-NC 和 30 名对照的静息态 MRI 数据。对三组之间的背外侧前额叶皮层 (DLPFC) 的假设驱动的基于种子的功能连接进行了比较，并与 BDT 性能相关联。我们发现测试（SERIAL ORDER > ANY ORDER 中的损害）和组（（NC = PD-NC）> PD-MCI）对 BDT 性能的主要影响在控制 ANY ORDER 变异性时在 SERIAL ORDER 中更为明显，但是反之亦然。此外，与其他组相比，PD-MCI 的特点是双侧 DLPFC 和小脑之间的功能断开。在功能相关性中，DLPFC 连接性与 SERIAL- 和 ANY-ORDER 性能均呈正相关。综上所述，