Localized histiocytic sarcoma may occur as a primary lesion in periarticular tissues of large appendicular joints. Treatment options for the primary lesion include radical surgical excision, radiation therapy (RT), or both, in combination with chemotherapy for potential systemic metastases. In an effort to better characterize the time to progression (TTP) following surgical vs non‐surgical approaches for periarticular histiocytic sarcoma (PAHS), a contemporary European population of affected dogs was retrospectively surveyed. Medical records were queried for newly‐diagnosed PAHS cases undergoing surgery (predominantly limb amputation) or RT followed by systemic chemotherapy. Of 49 dogs, 34 underwent RT and 15 underwent surgery. All dogs received adjuvant chemotherapy. There was no statistically significant difference in TTP or overall survival between groups. The median TTP was 336 days for the operated dogs and 217 days for the irradiated dogs (P = .117). The median overall survival time was 398 days for the operated dogs and 240 days for the irradiated dogs (P = .142). On multi‐variable analysis, the variables significantly associated with an increased risk of both tumour progression and tumour‐related death were regional lymph node and distant metastasis at admission. Survival and local control rates following RT may be comparable to radical resection. These data may better inform shared decision‐making processes between multi‐disciplinary care providers and owners.

中文翻译：

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放疗和手术作为犬关节周围组织细胞肉瘤的主要治疗方法的结果比较：意大利兽医肿瘤学会的一项研究。

局部组织细胞肉瘤可能是大附肢关节周围组织的原发病变。原发病变的治疗选择包括根治性手术切除、放射治疗 (RT) 或两者，并结合化疗治疗潜在的全身转移。为了更好地描述关节周围组织细胞肉瘤 (PAHS) 手术与非手术方法后进展时间 (TTP) 的特征，对当代欧洲患病犬群进行了回顾性调查。对接受手术（主要是截肢）或放疗后接受全身化疗的新诊断 PAHS 病例的医疗记录进行了查询。在 49 只狗中，34 只接受了放疗，15 只接受了手术。所有的狗都接受了辅助化疗。组间 TTP 或总生存期没有统计学显着差异。手术犬的中位 TTP 为 336 天，辐照犬为 217 天（P = .117）。手术犬的中位总生存时间为 398 天，辐照犬为 240 天 ( P = .142)。在多变量分析中，与肿瘤进展和肿瘤相关死亡风险增加显着相关的变量是入院时的区域淋巴结和远处转移。放疗后的存活率和局部控制率可能与根治性切除术相当。这些数据可以更好地为多学科护理提供者和所有者之间的共享决策过程提供信息。