Images show the engraftment of endothelial cells derived from hemophilia A patients' induced pluripotent stem cells with enforced expression of coagulation factor VIII. Upper right image shows these cells in NSG mice at 16 weeks after being transplanted. Lower left image shows the vessel‐like network generated by these cells in hemophilia A mice at 2 weeks after being transplanted.

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封面

图像显示了源自血友病A患者的内皮细胞的移植，其中诱导的多能干细胞具有凝血因子VIII的强制表达。右上图显示了移植后16周时NSG小鼠中的这些细胞。左下图显示了这些细胞在移植2周后在A型血友病小鼠中生成的血管样网络。