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Practical Decagram‐Scale Synthesis of a Lamellarin Analogue and Deprotection of Lamellarin Isopropyl Ethers
European Journal of Organic Chemistry ( IF 2.8 ) Pub Date : 2020-05-11 , DOI: 10.1002/ejoc.202000499
Robin Klintworth 1 , Charles B. de Koning 1 , Joseph P. Michael 1
Affiliation  

Lamellarin ε and dehydrolamellarin J were synthesized via enaminones by operationally simple routes that included a mild new method for the nearly quantitative deprotection of isopropyl‐protected phenols with methanesulfonic acid. The synthesis of dehydrolamellarin J could be scaled up to provide over 25 g of product without the need for chromatography.
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中文翻译:

Lamellarin类似物的实用十克规模合成和Lamellarin异丙醚的脱保护

Lamellarinε和Dehydrolamellarin J是通过操作简单的途径通过烯胺酮合成的,其中包括使用温和的新方法对异丙基保护的苯酚进行甲磺酸近乎定量的脱保护。可以扩大脱氢薄片蛋白J的合成规模,从而无需色谱即可提供超过25 g的产物。
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更新日期:2020-07-01
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