This study aimed to systematically review studies focusing on levels of physical activity (PA) in people with epilepsy (PWE) compared with non‐epilepsy controls, and identify factors associated with PA in PWE. Intervention studies were also reviewed to consider the effects of psychological interventions on levels of PA, and the effects of PA‐based interventions on seizure activity, psychiatric comorbidity, and health‐related quality of life (HRQoL). PRISMA guidelines were followed. Searches were conducted using PubMed, Cochrane Controlled Register of Trials, PsycINFO, and Embase. Forty‐six studies met inclusion criteria, including case‐control, cross‐sectional, and intervention studies. Assessment measures included questionnaires, activity trackers, and measures of physiological fitness. Twelve of 22 (54.5%) case‐control studies utilizing self‐report questionnaire measures reported that PWE were performing lower levels of PA, less likely to be engaging in PA, or less likely to meet PA guidelines than controls. The remaining studies did not find a difference between PWE and controls. Eight of 12 (67%) case‐control studies utilizing exercise/fitness tests reported that PWE performed significantly poorer than controls, whereas in two studies PWE performed better than controls. One of three studies investigating the relationship between PA and seizure frequency found that increased self‐reported PA was associated with having fewer seizures, whereas two did not find a significant relationship. All seven cross‐sectional studies that included measures of HRQoL and depression/anxiety found a positive relationship between levels of PA and HRQoL/reduced levels of depression and anxiety. All four studies that used PA‐based interventions demonstrated improvements in levels of PA and increased HRQoL. Study quality was almost universally low. In conclusion, there is some evidence that PWE engage in less PA than peers, and that interventions can improve PA levels and HRQoL. However, there is a need for more robust study designs to better understand PA in individuals with epilepsy.

中文翻译：

---

癫痫患者的体力活动：系统评价

本研究旨在系统地回顾关注癫痫患者 (PWE) 与非癫痫对照者的体力活动 (PA) 水平的研究，并确定 PWE 中与体力活动相关的因素。还审查了干预研究，以考虑心理干预对 PA 水平的影响，以及基于 PA 的干预对癫痫活动、精神共病和健康相关生活质量 (HRQoL) 的影响。遵循 PRISMA 指南。使用 PubMed、Cochrane Controlled Register of Trials、PsycINFO 和 Embase 进行检索。46 项研究符合纳入标准，包括病例对照研究、横断面研究和干预研究。评估措施包括问卷、活动追踪器和生理健康措施。22 个中的 12 个 (54. 5%) 使用自我报告问卷测量的病例对照研究报告说，与对照组相比，PWE 执行的 PA 水平较低，不太可能参与 PA，或者不太可能符合 PA 指南。其余研究未发现 PWE 和对照之间存在差异。12 项（67%）病例对照研究中的 8 项使用运动/体能测试报告 PWE 的表现明显低于对照组，而在两项研究中 PWE 的表现优于对照组。调查 PA 与癫痫发作频率之间关系的三项研究中的一项发现，自我报告的 PA 增加与癫痫发作次数减少有关，而两项没有发现显着关系。包括 HRQoL 和抑郁/焦虑测量在内的所有七项横断面研究都发现 PA 水平与 HRQoL/抑郁和焦虑水平降低之间存在正相关关系。使用基于 PA 的干预措施的所有四项研究都表明 PA 水平有所改善，HRQoL 增加。研究质量几乎普遍较低。总之，有一些证据表明 PWE 参与的 PA 比同龄人少，并且干预可以提高 PA 水平和 HRQoL。然而，需要更稳健的研究设计来更好地了解癫痫患者的 PA。并且干预可以提高 PA 水平和 HRQoL。然而，需要更稳健的研究设计来更好地了解癫痫患者的 PA。并且干预可以提高 PA 水平和 HRQoL。然而，需要更稳健的研究设计来更好地了解癫痫患者的 PA。