This is the first work to load HPMC and PVP by the lansoprazole (LPZ) through supercritical solvent impregnation (SSI). The process was carried out at laboratory scale under various sets of conditions in terms of pressure (150−250 bar), temperature (308−328 K), and impregnation time (60−180 min). The results showed that an increase in any of the investigated parameters increased the drug loading, and that the temperature imposed the strongest effect on the drug loading. Moreover, impregnation loadings onto the PVP and HPMC were found to range from 0.56% to 0.61% and from 1.16% to 1.30%, respectively. For both polymers, the best results were obtained at a pressure of 250 bar and a temperature of 328 K with an impregnation time of 180 min. The processed drug was further investigated by XRD, SEM, DSC, FTIR, and DLS analyses. The final results indicated superior loading of the drug onto the HPMC rather than the PVP.

这是兰索拉唑（LPZ）通过超临界溶剂浸渍（SSI）加载HPMC和PVP的第一项工作。该过程在实验室规模下在各种条件下进行，涉及压力（150-250 bar），温度（308-328 K）和浸渍时间（60-180 min）。结果表明，任何研究参数的增加都会增加载药量，而温度对载药量的影响最大。此外，发现PVP和HPMC上的浸渍负荷分别为0.56％至0.61％和1.16％至1.30％。对于这两种聚合物，在250 bar的压力和328 K的温度以及180分钟的浸渍时间下都可获得最佳结果。通过XRD，SEM，DSC，FTIR和DLS分析进一步研究了加工后的药物。