Programmed cell death-ligand 1 (PD-L1) is a glycoprotein that is expressed on the cell surface of both hematopoietic and nonhematopoietic cells. PD-L1 play a role in the immune tolerance and protect self-tissues from immune system attack. Dysfunction of this molecule has been highlighted in the pathogenesis of tumors, autoimmunity, and infectious disorders. MicroRNAs (miRNAs) are endogenous molecules that are classified as small non-coding RNA with approximately 20–22 nucleotides (nt) length. The function of miRNAs is based on complementary interactions with target mRNA via matching completely or incompletely. The result of this function is decay of the target mRNA or preventing mRNA translation. In the past decades, several miRNAs have been discovered which play an important role in the regulation of PD-L1 in various malignancies. In this review, we discuss the effect of miRNAs on PD-L1 expression and consider the effect of miRNAs on the synthetic pathway of PD-L1, especially during cancers.

程序性细胞死亡配体1（PD-L1）是一种糖蛋白，可在造血和非造血细胞的细胞表面表达。PD-L1在免疫耐受中发挥作用，并保护自身组织免受免疫系统攻击。该分子的功能异常在肿瘤，自身免疫和感染性疾病的发病机理中得到了强调。MicroRNA（miRNA）是内源性分子，被归类为小的非编码RNA，长度约为20-22个核苷酸（nt）。miRNA的功能基于通过完全或不完全匹配与靶mRNA的互补相互作用。该功能的结果是靶mRNA的降解或阻止mRNA翻译。在过去的几十年中，已经发现了几种miRNA，它们在各种恶性肿瘤的PD-L1调控中起着重要作用。在这篇评论中