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Fluorescent sensors for the detection of hydrazine in environmental and biological systems: Recent advances and future prospects
Coordination Chemistry Reviews ( IF 20.6 ) Pub Date : 2020-05-11 , DOI: 10.1016/j.ccr.2020.213367
Xiang-Yang Zhang , Yu-Shun Yang , Wei Wang , Qing-Cai Jiao , Hai-Liang Zhu

Being a widely used raw material in the manufacture of synthetic catalysts, agricultural chemicals and pharmaceutical products, hydrazine (N2H4) caused irreversible pollution to air, water and soil in our environment owing to its high toxic impact and massive use. In addition, during the metabolism process of certain drugs, such as isoniazid (INH), hydrazine can also be released, causing serious harm to human body. It has been proved by previous researches that hydrazine could cause several adverse effects, including the inhibition of molecular metabolism, mitochondrial oxidation and DNA damage. Thus, methods which could sensitively and selectively detect hydrazine in vivo and in vitro are in urgent need. Fluorescent sensors, a powerful tool for efficiently evaluating the hydrazine levels in environmental and living systems with minimal perturbation, were widely studied over the past few years. Since the number of the fluorescent sensors for hydrazine detection has grown rapidly, this review attempted to present a well-organized overview of existing design strategies for developing fluorescent sensors for hydrazine, including both reaction-based sensors and material-based sensors from 2011 to the present. The molecular structures, sensing mechanisms and applications of these sensors were emphatically classified and discussed. Moreover, the following prospects and challenges of this field were also provided.



中文翻译:

用于检测环境和生物系统中肼的荧光传感器:最新进展和未来前景

肼(N 2 H 4)作为合成催化剂,农用化学品和医药产品的生产中广泛使用的原料,由于其剧毒影响和大量使用,对我们的环境中的空气,水和土壤造成不可逆转的污染。此外,在某些药物(例如异烟肼(INH))的代谢过程中,还会释放出肼,从而对人体造成严重伤害。先前的研究已证明肼可引起多种不良反应,包括抑制分子代谢,线粒体氧化和DNA损伤。因此,可以在体内体外灵敏和选择性地检测肼的方法迫切需要。在过去的几年中,荧光传感器是一种功能强大的工具,可有效地评估环境和生活系统中的肼水平,且干扰最小。由于用于肼检测的荧光传感器的数量迅速增长,因此本综述试图对开发用于肼的荧光传感器的现有设计策略进行有条理的概述,包括从2011年到2007年的基于反应的传感器和基于材料的传感器。当下。着重对这些传感器的分子结构,传感机理和应用进行了分类和讨论。此外,还提供了该领域的以下前景和挑战。

更新日期:2020-05-11
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