Bharath et al., 2020 report that CD4⁺ T lymphocytes from aged individuals exhibit defective mitochondrial autophagy, resulting in altered redox metabolism and upregulation of TH17 cytokines, which in turn may contribute to aging-associated chronic inflammation or “inflammaging.” Of note, the antiaging drug metformin reverses this autophagy defect and rejuvenates CD4⁺ T cell function.

中文翻译：

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CD4 + T细胞位于发炎中心。

Bharath等人（2020年）的报告显示，老年个体的CD4 ⁺ T淋巴细胞线粒体自噬缺陷，导致氧化还原代谢改变和TH17细胞因子上调，进而可能导致与衰老相关的慢性炎症或“炎症”。值得注意的是，抗衰老药物二甲双胍可逆转这种自噬缺陷并恢复CD4 ⁺ T细胞功能。