Introduction and objectives

Surrogate biomarkers of liver fibrosis developed in tertiary care are increasingly used in general populations. We evaluated the association between liver stiffness (LS) and five continuous (AST/ALT, APRI, Forns Index, FIB-4, GGT) and two discrete biomarkers (BARD, BAAT) in a general population.

Patients and methods

636 (29%) of the 2159 citizens of the Bagnacavallo Study had LS measured by transient elastography. Using linear regression with univariate multiple imputation, we evaluated the association of LS with the above biomarkers in the total sample of 2159 citizens.

Results

The mean change of LS between the 5^th and 9^5th internal percentile of any continuous biomarker was ≤1 kPa. The mean change of LS between scores 0 and 3 of BARD and scores 0 and ≥3 of BAAT was >1 kPa but of doubtful clinical relevance.

Conclusion

We found a modest association between LS and seven biomarkers of liver fibrosis in a general population.

中文翻译：

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在一般人群中，常用的肝纤维化生物标志物与肝硬度之间是否存在关联？

介绍和目标

在三级医疗中发展起来的肝纤维化的替代生物标志物在普通人群中越来越多地使用。我们评估了一般人群中肝脏硬度（LS）与五个连续指标（AST / ALT，APRI，Forns指数，FIB-4，GGT）和两个离散生物标志物（BARD，BAAT）之间的关联。

患者和方法

Bagnacavallo研究的2159名公民中有636名（29％）通过瞬时弹性成像测量了LS。使用线性回归和单变量多重推算，我们在2159名市民的总样本中评估了LS与上述生物标记的关联。

结果

在任何连续生物标记的^第5^个和^第9个^第5^个内部百分位数之间LS的平均变化≤1 kPa。在BARD的0分和3分以及BAAT的0分和≥3分之间，LS的平均变化> 1 kPa，但临床相关性值得怀疑。

结论

我们发现一般人群中LS与肝纤维化的七个生物标志物之间存在适度的关联。