INTRODUCTION Arm and hand function deficits are commonly in people with multiple sclerosis (PwMS). The Arm Function in Multiple Sclerosis Questionnaire (AMSQ) is a novel self-administered instrument specifically developed to evaluate upper limb function in MS. The aim of this study was to translate and adapt the AMSQ into Italian and to assess its psychometric properties in PwMS. Validity (structural, construct, and known-groups) and reliability (internal consistency, test-retest, and measurement error) were assessed. MATERIALS AND METHODS From June 2017 to February 2018, a prospective cohort of PwMS among those followed as outpatients at the Rehabilitation Services of the Italian Multiple Sclerosis Society (AISM) of Genoa, Padua, and Vicenza was involved in the study. Construct validity of AMSQ was determined by examining correlations with the Italian version of ABILHAND, Modified Fatigue Impact Scale (MFIS), and Functional Independence Measure (FIM). RESULTS A total of 234 PwMS were enrolled. The mean AMSQ total score was 67.3 (SD = 38.4). Factor analysis results suggested one factor. As expected, moderate to high correlation coefficients were found between AMSQ and ABILHAND (- 0.79), MFIS (0.50) and its subsets, and FIM (- 0.60) and its subsets involving upper limb functioning. PwMS with higher EDSS reported worse total score of AMSQ than patients with low disability. The internal consistency of the 31 items was high (Cronbach's α, 0.98). Test-retest reliability, as measured with ICC, was 0.96 (95% IC, 0.93-0.98), and measurement error was about 8.3 points showing good reliability. DISCUSSION AMSQ has been adapted and validated, it is a reliable questionnaire for Italian PwMS.

中文翻译：

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意大利对多发性硬化症问卷中手臂功能的验证。

引言多发性硬化症（PwMS）患者通常会出现手臂和手部功能障碍。多发性硬化症问卷中的手臂功能（AMSQ）是一种新型的自行管理的器械，专门用于评估MS的上肢功能。这项研究的目的是将AMSQ翻译和改编为意大利语，并评估其在PwMS中的心理计量特性。评估有效性（结构，构造和已知群体）和可靠性（内部一致性，重测和测量误差）。材料与方法从2017年6月至2018年2月，在意大利热那亚，帕多瓦和维琴察的多发性硬化症协会（AISM）康复服务的门诊患者中纳入了PwMS的前瞻性队列。通过检查与意大利版本的ABILHAND，修正的疲劳影响量表（MFIS）和功能独立性量度（FIM）的相关性来确定AMSQ的构建有效性。结果总共招募了234名PwMS。平均AMSQ总得分为67.3（标准差= 38.4）。因素分析结果提示一个因素。不出所料，在AMSQ和ABILHAND（-0.79），MFIS（0.50）及其子集以及FIM（-0.60）及其子集与上肢功能之间发现了中等到高的相关系数。EDSS较高的PwMS报告的AMSQ总分比低残疾的患者差。这31个项目的内部一致性很高（Cronbach'sα，0.98）。用ICC测得的重测可靠性为0.96（95％IC为0.93-0.98），测量误差约为8.3点，显示出良好的可靠性。