The plant Teucrium polium (T.p.) possesses a wide range of pharmacological activities due to the presence, in particular, of different phytochemicals, phenols and flavonoids. We examined the effects of the T.p. extract on impulse activity of hippocampal neurons in rats with a model of Alzheimer’s disease. Adult albino rats were divided into three groups (5 animals in each). The control group C obtained intracerebroventricular (i.c.v.) infusions of saline, animals of group Aβ were i.c.v. infused with amyloid β peptide 25–35, Aβ(25–35), and group Aβ+T.p. was treated by both Aβ(25–35) infusions and introductions of the T.p. extract. In group Aβ, a greater proportion of hippocampal neurons with post-tetanic depression after high-frequency stimulation of the entorhinal cortex, lower values of the frequency of background activity generated by the above neurons, and relatively weaker modifications of spike activity (post-tetanic potentiation and depression) were observed. Daily administrations of the T.p. extract partially but considerably reversed the above-mentioned negative shifts in spike activity of hippocampal neurons caused by Aβ(25–35). We suggest that T.p. extract containing important phytochemicals is capable of ameliorating the memory dysfunction caused by Aβ(25–35) via blocking amyloid deposition and a positive influence on the functions of hippocampal neurons.

中文翻译：

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阿尔茨海默病大鼠模型中海马神经元的强直后增强和抑制：Teucrium Polium 提取物的影响

由于存在不同的植物化学物质、酚类和类黄酮，植物 Teucrium polium (Tp) 具有广泛的药理活性。我们研究了 Tp 提取物对阿尔茨海默病模型大鼠海马神经元冲动活动的影响。成年白化大鼠被分为三组（每组 5 只）。对照组C获得脑室内（icv）输注生理盐水，Aβ组动物icv注射淀粉样β肽25-35，Aβ（25-35），Aβ+Tp组同时接受Aβ（25-35）治疗Tp 提取物的注入和引入。在 Aβ 组中，高频刺激内嗅皮层后出现破伤风后抑郁的海马神经元比例更高，观察到由上述神经元产生的背景活动频率的较低值，以及相对较弱的尖峰活动修改（强直后增强和抑制）。每日服用 Tp 提取物部分但显着逆转了上述由 Aβ(25-35) 引起的海马神经元尖峰活动的负面变化。我们建议含有重要植物化学物质的 Tp 提取物能够通过阻断淀粉样蛋白沉积和对海马神经元功能的积极影响来改善由 Aβ(25-35) 引起的记忆功能障碍。提取物部分但显着逆转了上述由 Aβ(25-35) 引起的海马神经元尖峰活动的负变化。我们建议含有重要植物化学物质的 Tp 提取物能够通过阻断淀粉样蛋白沉积和对海马神经元功能的积极影响来改善由 Aβ(25-35) 引起的记忆功能障碍。提取物部分但显着逆转了上述由 Aβ(25-35) 引起的海马神经元尖峰活动的负变化。我们建议含有重要植物化学物质的 Tp 提取物能够通过阻断淀粉样蛋白沉积和对海马神经元功能的积极影响来改善由 Aβ(25-35) 引起的记忆功能障碍。