Nobel committee has awarded William G. Kaelin, Jr., Sir Peter J. Ratcliffe and Gregg L. Semenza Nobel Prize in Medicine this year for their remarkable discoveries in how cell sense low level of oxygen and rapidly adapts to the changing environment. Hypoxia is often considered to be the main regulator of cancer, since it promotes metabolic changes of the cell. Inhibition of signal transduction pathway and transcriptional regulators can be used as a therapeutic approach to control cancer progression.

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2019年诺贝尔生理学和医学奖：氧气感应和适应性反应从细胞台到床旁的漫长道路

诺贝尔奖委员会授予了小威廉·G·凯林，彼得·J·拉特克利夫爵士和格雷格·L·塞门扎·格伦·诺贝尔医学奖，以表彰他们在细胞如何感知低水平的氧气并迅速适应不断变化的环境方面的杰出发现。低氧症通常被认为是癌症的主要调节剂，因为它促进细胞的代谢变化。信号转导途径和转录调节因子的抑制可用作控制癌症进展的治疗方法。