Superoxide dismutase (SOD) is known to be protective against oxidative stress-mediated skin dysfunction. Here we explore the potential therapeutic activities of RM191A, a novel SOD mimetic, on skin. RM191A is a water soluble, dimeric copper (Cu²⁺-Cu³⁺)-centred polyglycine coordination complex. It displays 10-fold higher superoxide quenching activity compared to SOD as well as significant anti-inflammatory activity through beneficial modulation of several significant inflammatory pathways in cells.

中文翻译：

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新型超氧化物歧化酶模拟物RM191A的皮肤保护作用

已知超氧化物歧化酶（SOD）可以抵抗氧化应激介导的皮肤功能障碍。在这里，我们探讨了新型的SOD模拟物RM191A对皮肤的潜在治疗作用。RM191A是一种以水溶性二聚铜（Cu ²⁺ -Cu ³⁺）为中心的聚甘氨酸配位络合物。与SOD相比，它具有10倍的超氧化物猝灭活性，并且通过对细胞中几种重要炎症途径的有益调节，具有显着的抗炎活性。